Chinese Journal of Applied Chemistry ›› 2023, Vol. 40 ›› Issue (9): 1258-1266.DOI: 10.19894/j.issn.1000-0518.230045
• Full Papers • Previous Articles Next Articles
Jia-Hui LIU1,2, Bai-Chao AN3,4, Qiu-Yan YAN1(), Shi-Fang LUAN1,2
Received:
2023-03-03
Accepted:
2023-07-12
Published:
2023-09-01
Online:
2023-09-14
Contact:
Qiu-Yan YAN
About author:
qyyan@ciac.ac.cnSupported by:
CLC Number:
Jia-Hui LIU, Bai-Chao AN, Qiu-Yan YAN, Shi-Fang LUAN. Preparation and Properties of Mussel-Inspired Antibacterial Bone Adhesive[J]. Chinese Journal of Applied Chemistry, 2023, 40(9): 1258-1266.
Add to citation manager EndNote|Ris|BibTeX
URL: http://yyhx.ciac.jl.cn/EN/10.19894/j.issn.1000-0518.230045
Fig.1 (A) Schematic illustration of fabrication of bone adhesive; (B) Schematic illustration of the synthesis of OHA; (C) FT-IR spectra of HA and OHA; (D) 1H NMR spectra of HA and OHA
Fig.2 (A) FT-IR spectra of OHA@PL;(B) Gelation process monitoring of OHA@PL@TA by rheological analysis; (C) Amplitude sweep results of OHA@PL@TA with different mass fraction of TA; (D) Strain sweep results of OHA@PL@TA; (E) Oscillation strain sweep of OHA@PL@TA followed by time sweep with high strains and low strains; (F) Viscosity change of OHA@PL@TA with the increase of shear rate
Fig.3 (A) Experiment set-up of lap-shear adhesion strength test. The lap-shear adhesion strength of OHA@PL@TA with different of the concentration of TA, when the concentration of PL respectively was 3%(B), 4%(C), 5%(D), 6%(E) and 7%(F) (***represents P<0. 001,ns represents P>0.05, n=3)
Fig.4 (A) Experiment set-up of end-to-end adhesion strength test. The end-to-end adhesion strength of OHA@PL@TA with different of the concentration of TA, when the concentration of PL respectively was 3%(B), 4%(C), 5%(D), 6%(E) and 7%(F)(*represents P<0.05,***represents P<0.001,ns represents P>0.05, n=3)
Fig.5 (A) Images of survival S.aureus clones on the culture plate after being co-cultured with samples; (B) Images of survival E.coil clones on the culture plate after being co-cultured with samples; (C) S.aureus and (D) E.coli with filtering papers incubated with leach liquor of samples placed on the agar petri dish to analyse the inhibition zone (Zone 1, 2, 3 and 4 stand for control, OHA, OHA@PL and OHA@PL@TA group, respectively). Quantitative results of S.aureus(E) and E.coli(F) co-cultured with PBS and those samples, respectively (***represents P<0.001, n=3)
Fig.6 (A) Live/Dead staining of MC-3T3 after treating with samples for 24 h; (B) Cell viability of MC-3T3 treated with samples for 24 h (ns represents P>0.05, n=3)
1 | ZHANG M R, LIU J X, ZHU T T, et al. Functional macromolecular adhesives for bone fracture healing[J]. ACS Appl Mater Interfaces, 2022, 14(1): 1-19. |
2 | KOONS G L, DIBA M, MIKOS A G. Materials design for bone-tissue engineering[J]. Nat Rev Mater, 2020, 5(8): 584-603. |
3 | TANG J C, XI K, CHEN H, et al. Flexible osteogenic glue as an all In one solution to assist fracture fixation and healing[J]. Adv Funct Mater, 2021, 31(38): 2102465. |
4 | BAI S M, ZHANG X L, LV X L, et al. Bioinspired mineral-organic bone adhesives for stable fracture fixation and accelerated bone regeneration[J]. Adv Funct Mater, 2019, 30(5): 1908381. |
5 | XU L J, GAO S, ZHOU R B, et al. Bioactive pore-forming bone adhesives facilitating cell ingrowth for fracture healing[J]. Adv Mater, 2020, 32(10): e1907491. |
6 | 王绪凯, 杨佳臻, 丁建勋. 双网络增强手性超分子水凝胶促进成骨[J].应用化学, 2022, 39(10): 1627-1628. |
WANG X K, YANG J Z, DING J X. Double network-enhanced chiral supramolecular hydrogel to promote osteogenesis[J]. Chin J Appl Chem, 2022, 39(10): 1627-1628. | |
7 | HUANG B X, CHEN M J, TIAN J, et al. Oxygen-carrying and antibacterial fluorinated nano-hydroxyapatite incorporated hydrogels for enhanced bone regeneration[J]. Adv Healthc Mater, 2022, 11(12): e2102540. |
8 | HUANG W J, CHENG S, WANG X L, et al. Noncompressible hemostasis and bone regeneration induced by an absorbable bioadhesive self-healing hydrogel[J]. Adv Funct Mater, 2021, 31(22): 2009189. |
9 | ZHOU D, LI S Z, PEI M J, et al. Dopamine-modified hyaluronic acid hydrogel adhesives with fast-forming and high tissue adhesion[J]. ACS Appl Mater Interfaces, 2020, 12(16): 18225-18234. |
10 | ZHU D Q, WANG H Y, TRINH P, et al. Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration[J]. Biomaterials, 2017, 127: 132-140. |
11 | WU T L, CUI C Y, HUANG Y T, et al. Coadministration of an adhesive conductive hydrogel patch and an injectable hydrogel to treat myocardial infarction[J]. ACS Appl Mater Interfaces, 2020, 12(2): 2039-2048. |
12 | A S, XU Q, JOHNSON M, et al. An injectable multi-responsive hydrogel as self-healable and on-demand dissolution tissue adhesive[J]. Appl Mater Today, 2021, 22: 100967. |
13 | DEGEN G D, STOW P R, LEWIS R B, et al. Impact of molecular architecture and adsorption density on adhesion of mussel-inspired surface primers with catechol-cation synergy[J]. J Am Chem Soc, 2019, 141(47): 18673-18681. |
14 | WANG B, LIU J, NIU D Y, et al. Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration[J]. ACS Appl Mater Interfaces, 2021, 13(28): 32673-32689. |
15 | LIU Y H, ZHU Z, PEI X B, et al. ZIF-8-modified multifunctional bone-adhesive hydrogels promoting angiogenesis and osteogenesis for bone regeneration[J]. ACS Appl Mater Interfaces, 2020, 12(33): 36978-36995. |
16 | CHEN K W, LIN Q X, WANG L B, et al. An all-in-one tannic acid-containing hydrogel adhesive with high toughness, notch insensitivity, self-healability, tailorable topography, and strong, instant, and on-demand underwater adhesion[J]. ACS Appl Mater Interfaces, 2021, 13(8): 9748-9761. |
17 | YANG K, ZHOU X Y, LI Z L, et al. Ultrastretchable, self-healable, and tissue-adhesive hydrogel dressings involving nanoscale tannic acid/ferric ion complexes for combating bacterial infection and promoting wound healing[J]. ACS Appl Mater Interfaces, 2022, 14(38): 43010-43025. |
18 | ZHAO X D, PEI D D, YANG Y X, et al. Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment[J]. Adv Funct Mater, 2021, 31(18): 2009442. |
19 | KIM K, SHIN M, KOH M Y, et al. TAPE: a medical adhesive inspired by a ubiquitous compound in plants[J]. Adv Funct Mater, 2015, 25(16): 2402-2410. |
20 | NAM S, MOONEY D. Polymeric tissue adhesives[J]. Chem Rev, 2021, 121(18): 11336-11384. |
21 | TIU B D B, DELPARASTAN P, NEY M R, et al. Cooperativity of catechols and amines in high-performance dry/wet adhesives[J]. Angew Chem Int Ed Engl, 2020, 59(38): 16616-16624. |
22 | KIM S, YOO H Y, HUANG J, et al. Salt triggers the simple coacervation of an underwater adhesive when cations meet aromatic π electrons in seawater[J]. ACS Nano, 2017, 11(7): 6764-6772. |
23 | ZHU H F, MEI X H, HE Y Y, et al. Fast and high strength soft tissue bioadhesives based on a peptide dendrimer with antimicrobial properties and hemostatic ability[J]. ACS Appl Mater Interfaces, 2020, 12(4): 4241-4253. |
24 | GUO H L, HUANG S, XU A D, et al. Injectable adhesive self-healing multiple-dynamic-bond crosslinked hydrogel with photothermal antibacterial activity for infected wound healing[J]. Chem Mater, 2022, 34(6): 2655-2671. |
25 | JIN X, XIONG Y H, ZHANG X Y, et al. Self‐sdaptive sntibacterial porous implants with sustainable eesponses for infected bone defect therapy[J]. Adv Funct Mater, 2019, 29(17): 1807915. |
26 | SUN L W, SONG L J, LUAN S F, et al. Progress in photo-initiated living graft polymerization of biomaterials[J]. Acta Polym Sin, 2021, 52(3): 223-234. |
27 | LIU Z T, YI Y Z, WANG S J, et al. Bio-inspired self-adaptive nanocomposite array: from non-antibiotic antibacterial actions to cell proliferation[J]. ACS Nano, 2022, 16(10): 16549-16562. |
28 | DING M, ZHAO W, SONG L J, et al. Stimuli-responsive nanocarriers for bacterial biofilm treatment[J]. Rare Met, 2022, 41(2): 482-498. |
29 | CAO D, DING J. Recent advances in regenerative biomaterials[J]. Regener Biomater, 2022, 9: rbac098. |
30 | 刘慧, 刘骁, 曹远桥, 等. 氨基酸基聚合物在抗菌领域的研究进展[J]. 应用化学, 2021, 38(5): 559-571. |
LIU H, LIU X, CAO Y Q, et al. Research progress on amino acid-based antimicrobial polymers[J]. Chin J Appl Chem, 2021, 38(5): 559-571. | |
31 | 孙振龙, 闫顺杰, 周容涛, 等. 基于抗菌肽的智能型抗菌涂层研究进展[J]. 应用化学, 2020, 37(8): 865-876. |
SUN Z L, YAN S J, ZHOU R T, et al. Recent progress in the development of smart coatings based on antimicrobial peptides[J]. Chin J Appl Chem, 2020, 37(8): 865-876. |
[1] | Yu-Jie MA, Ying-Xin ZHANG, Huan-Yan DAI, Zhi-Min XU, Bing HAN. Preparation and Properties of 3D Printed nHA/PEEK-AgNPs Composite Porous Scaffolds [J]. Chinese Journal of Applied Chemistry, 2023, 40(4): 536-545. |
[2] | Wei-Na HAO, Chao ZHOU, Hai-Ping DI, Lin-Hong DENG. Preparation and Characterization of Graphene Oxide-Hyaluronic Acid-Polyethylene Glycol Composite Supramolecular Hydrogel [J]. Chinese Journal of Applied Chemistry, 2023, 40(12): 1672-1681. |
[3] | Guo-Qing CAI, Jing-Ru DONG, Jun-Ming MO. Green Synthesis and Antibacterial Activity of N‑Benzyl Sulfoximines [J]. Chinese Journal of Applied Chemistry, 2023, 40(12): 1693-1699. |
[4] | Xiao-Ming XIE, Jia-Qi ZHANG. Hydrogen Bond Interaction Driven Procyanidine Assembly into Underwater Adhesive with Antibacterial Activity [J]. Chinese Journal of Applied Chemistry, 2022, 39(10): 1533-1542. |
[5] | YANG Jia-Qiang,WU Xue-Jiao, ZHOU Xu-Rong, DENG Ling, YANG Hong. Synthesis and Antibacterial Activities of Osthole Ester Derivatives [J]. Chinese Journal of Applied Chemistry, 2021, 38(8): 917-922. |
[6] | Sha-Man LUO, Hao-Zhe SUN, Shi-Qiang YAN, Hui HUANG, Wei-Jia ZHANG, Jia WEI, Yan-Lei YU. Cell Biocompatibility of Photodeformable Azobenzene⁃containing Liquid Crystal Polymers [J]. Chinese Journal of Applied Chemistry, 2021, 38(10): 1371-1381. |
[7] | XING Yayan, SHI Yuzhe, DENG Shixian, ZHAO Baihan, LIU Zhiguo. Preparation and Application of Catechin-Silver Nanocomposites [J]. Chinese Journal of Applied Chemistry, 2020, 37(9): 1062-1068. |
[8] | YANG Jin,MA Qiseng,ZHONG Ying,ZHU Longbao,GE Fei,TAO Yugui,SONG Ping. Solid-Phase Synthesis of Cyclohexapeptide Thermoactinoamide A and Its Antibacterial Activity [J]. Chinese Journal of Applied Chemistry, 2019, 36(6): 677-682. |
[9] | LING Huiping,CHEN Xiaoqing,XIE Shengnan,CHEN Yuejian,SHE Zhigang,LIN Yongcheng,TAO Yiwen. Dihydroisocoumarin Compounds from Endophytic Fungi of Rhizophora apiculata and Its Antibacterial Activity [J]. Chinese Journal of Applied Chemistry, 2018, 35(6): 708-713. |
[10] | WEN Lijun, WANG Ying, LI Haixia, LI Juan. Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu [J]. Chinese Journal of Applied Chemistry, 2016, 33(9): 1056-1060. |
[11] | ZHAO Shengfang, CHEN Nianyou, ZHANG Hanmei, ZHANG Jing, LI Zaoying. Microwave Synthesis and Antibacterial Activity of Novel Asymmetric Porphyrin Matal Complexes from Substituted Piperonal [J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 542-546. |
[12] | FENG Jianhua, WU Gang. Synthesis, Structure and Antibacterial Activities of 4, 4', 6, 6'-Tetra(tert-butyl)-2, 2'-[ethylenedioxybis (nitrilomethylidyne)]diphenol and Its Cu(Ⅱ) Complex [J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 557-561. |
[13] | YANG Fengke, HAN Jian, WANG Yongchun, CHEN Fang. Synthesis and Biological Activity of Schiff Bases [J]. Chinese Journal of Applied Chemistry, 2015, 32(4): 392-398. |
[14] | ZHANG Tongtong1, LU Junrui1*, FENG Zhongnian1, LIU Jinbiao1, MU Jiangbei1, HOU Juezhuo2, BAO Xiurong1, XIN Chunwei1, WANG Meijun1. Synthesis and Antimicrobial Activities of Novel 1,2,4-Triazole Glucoside Derivatives [J]. Chinese Journal of Applied Chemistry, 2014, 31(09): 1050-1057. |
[15] | ZHANG Zhijian1*, KUANG Daizhi2, ZHANG Fuxing2, YU Jiangxi2, JIANG Wujiu2. Synthesis, Crystal Structure and Biological Activities of the Tris (2-methyl-2-phenyl) propyl Tin Trichloroacetic Acid Ester [J]. Chinese Journal of Applied Chemistry, 2014, 31(09): 1058-1062. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||