Chinese Journal of Applied Chemistry ›› 2023, Vol. 40 ›› Issue (11): 1539-1549.DOI: 10.19894/j.issn.1000-0518.230159
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Kai-Jun LEI1, Run-Run QIANG2, Huai-Guo LI1, Fang-Hao ZHENG1, Zi-Xue JIAO2, Zong-Liang WANG2, Yu WANG2, Ming-Feng HE1(), Pei-Biao ZHANG2()
Received:
2023-05-31
Accepted:
2023-10-16
Published:
2023-11-01
Online:
2023-12-01
Contact:
Ming-Feng HE,Pei-Biao ZHANG
About author:
zhangpb@ciac.ac.cnSupported by:
CLC Number:
Kai-Jun LEI, Run-Run QIANG, Huai-Guo LI, Fang-Hao ZHENG, Zi-Xue JIAO, Zong-Liang WANG, Yu WANG, Ming-Feng HE, Pei-Biao ZHANG. Preparation and Characterization of Shangkehuangshui/Polyvinyl Alcohol Electrospinning Nanofiber Membranes as Wound Dressing[J]. Chinese Journal of Applied Chemistry, 2023, 40(11): 1539-1549.
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URL: http://yyhx.ciac.jl.cn/EN/10.19894/j.issn.1000-0518.230159
Fig.2 SEM images of 4KX (A-D) and 25KX (E-H) of the electrospinning films of 10%PVA(A, E), PVA/HS 8%?2% (B, F), PVA/HS 10%?2% (C, G), PVA/HS 12%?2% (D, H)
Fig.3 The tensile stress-strain curves of the electrospinning films of PVA/HS 8%?2% (A), PVA/HS 10%?2% (B), PVA/HS 12%?2% (C); Tensile strength analysis (D); Elastic modulus analysis (E); Elongation at break analysis (F). *P<0.05, **P<0.01, ***P<0.001
Fig.5 (A) The percentage of cumulative drugs released and (B) the amount of cumulative drugs released of Shangkehuangshui/PVA electrospinning nanofiber films in traumatology with different drug load
Fig.6 Cytotoxicity analysis of different drug content of traumatology Shangkehuangshui/PVA electrostatic spinning nanofiber dressing, *P<0.05, ****P<0.0001
Fig.7 (A) Representative photos of wound healing effects of different materials on days 3-14; (B) Wound healing rate on the 3rd to 14th day. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001
Fig.8 (A) H&E staining of wound margin on days 7 and 14 (the bar indicates 100 μm). (B) Masson's trichromatic staining and magnification on day 14. (C) α-SMA immunohistochemical staining on days 7 and 14 (the bar indicates 100 μm). (D) Immunohistochemical staining of CD 31 on days 7 and 14 (the bar indicates 100 μm). (E) TNF-α and IL-6 immunofluorescence on days 3 and 7 (the bar indicates 50 μm)
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