Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (12): 1358-1363.DOI: 10.11944/j.issn.1000-0518.2015.12.150228

• Full Papers • Previous Articles     Next Articles

Preparation and Properties of Heparin Sodium/Polyvinyl Alcohol Composite Hydrogel

DENG Xinwang,HU Huiyuan(),LUO Zhongkuan,WU Maosheng,ZHOU Li   

  1. College of Chemistry and Chemical Engineering,Shenzhen University,Shenzhen,Guangdong 518060,China
  • Received:2015-07-03 Accepted:2015-08-24 Published:2015-12-01 Online:2015-12-01
  • Contact: HU Huiyuan
  • Supported by:
    Supported by Shenzhen Science and Technology Fund(No.JCYJ20140509172609151, No.JCYJ2013032910261471, No.JCYJ20120613112258764)

Abstract:

Heparin sodium/polyvinyl alcohol(HS/PVA) composite hydrogel was prepared successfully by the cyclic freezing-thawing method. Effects of mass fraction of heparin sodium on visible light transmittance, moisture content, hydrophilcity, mechanical property and percentage of heparin sodium release of composite hydrogel were studied. The results show that the introduction of heparin sodium into the structure of PVA can enhance the moisture content and hydrophilic of HS/PVA composite hydrogel, simultaneously, reduce visible light transmittance and mechanical properties of HS/PVA composite hydrogel. The release of heparin sodium from HS/PVA composite hydrogel resists the cell adhesion. Therefore, the HS/PVA composite hydrogel has a potential application in the fields of optical central materials of artificial cornea.

Key words: heparin sodium, polyvinyl alcohol, composite hydrogel, artificial cornea, cell adhesion