Synthesis, Crystal Structures and DNA Interaction of Nickel and Cadmium Complexes Involving Biimidazole

doi:10.11944/j.issn.1000-0518.2016.06.150350

Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (6): 710-718.DOI: 10.11944/j.issn.1000-0518.2016.06.150350

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Synthesis, Crystal Structures and DNA Interaction of Nickel and Cadmium Complexes Involving Biimidazole

YANG Lining^a^*(),HEI Jiahui^b,CHENG Zhao^a,Li li^a,YU Lili^a

^a Department of Pharmacy,Medical University of Xi'an,Xi'an 710021,China
^b Shaanxi Aerospace Staffs & Vocation University,Xi'an 710100,China

Received:2015-09-28 Accepted:2016-03-04 Published:2016-06-01 Online:2016-06-01
Contact: YANG Lining
Supported by:
Supported by the National Natural Science Foundation of China(No.81302706)

Abstract

Abstract:

Two complexes {[Ni(H₂biim)₃](phth)}(H₂biim=2,2'-biimidazole, phth=phthalate)(1) and [Cd(H₃biim)₂Cl₄](2) were synthesized under hydrothermal and common solution conditions, and characterized by elemental analysis, IR spectroscopy and single crystal X-ray diffraction analysis. Complex 1 consists of [Ni(H₂biim)₃]²⁺ cations hydrogen bonds with phthalate dianions. Each Ni atom coordinates six N atoms of three chelating biimidazole ligands in a pseudo-octahedral geometry. Complex 2 is a neutral compound. One N atom in H₂biim is protonated, forming a H₃biim⁺ cation. The central metal Cd is coordinated by two unidentate H₃biim⁺ ligands and four Cl atoms. The binding of the complexes with calf thymus DNA has been investigated by UV and fluorescence spectroscopy and viscosity measurement. All of the results indicate that the complexes 1 and 2 bind to DNA base pairs in intercalation and partial intercalation modes, respectively.

Key words: biimidazole, the nickel and cadmium complexes, crystal structure, DNA

YANG Lining, HEI Jiahui, CHENG Zhao, Li li, YU Lili. Synthesis, Crystal Structures and DNA Interaction of Nickel and Cadmium Complexes Involving Biimidazole[J]. Chinese Journal of Applied Chemistry, 2016, 33(6): 710-718.

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Synthesis, Crystal Structures and DNA Interaction of Nickel and Cadmium Complexes Involving Biimidazole

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