Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives

doi:10.3724/SP.J.1095.2011.00358

Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (04): 421-425.DOI: 10.3724/SP.J.1095.2011.00358

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Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives

WANG Rulin^*, JIANG Hongyan, QIN Shuzhu, WANG Peng

(Chemistry Department of Shanxi Medical University,Taiyuan 030001)

Received:2010-06-22 Revised:2010-10-27 Published:2011-04-10 Online:2011-04-10

Abstract

Abstract:

The inclusions of lornoxicam(LX) by β-cyclodextrin(β-CD), hydroxypropyl-β-cyclodextrin(HP-β-CD), and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy, differential scanning calorimetry(DSC) and NMR at different pH and temperature. The results showed that the 1∶1 inclusion compounds were formed between lornoxicam and CDs. Based on the formation constants, the interactions between lornoxicam and the three CDs follow an order of SBE-β-CD＞HP-β-CD＞β-CD.

Key words: β-cyclodextrin, fluorescence spectrometry, DSC, NMR

CLC Number:

O629.1
O626

WANG Rulin*, JIANG Hongyan, QIN Shuzhu, WANG Peng. Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, 2011, 28(04): 421-425.

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Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives

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