Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives

doi:10.3724/SP.J.1095.2012.00392

Chinese Journal of Applied Chemistry

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Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives

WANG Rulin^*, WANG Encheng, QIN Shuzhu, WANG Peng

(The Chemistry Department of Shanxi Medical University,Taiyuan 030001,China)

Received:2011-09-06 Revised:2011-11-23 Published:2012-08-10 Online:2012-08-10

Abstract

Abstract: The inclusion properties of piroxicam(PX) by β-cyclodextrin(β-CD), hydroxypropyl-β-cyclodextrin(HP-β-CD), and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy, differential scanning calorimetry(DSC) and NMR at different pH. The results showed that the 1∶2.5 inclusion compounds were formed between piroxicam and CDs. Based on the formation constants, which were 2.0×106, 1.8×106, 1.2×106 in neutral media, the inclusion capacity showed the order of SBE-β-CD＞HP-β-CD＞β-CD.

Key words: piroxicam, &, beta, -cyclodextrin, fluorescence spectroscopy, DSC, NMR

CLC Number:

O629.1
O626

WANG Rulin*, WANG Encheng, QIN Shuzhu, WANG Peng. Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2012.00392.

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Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives

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