Chinese Journal of Applied Chemistry

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Layer-by-Layer Assembled Antibacterial Microgel Films on Urethral Catheter

WANG Zunzhi1*, ZHANG Jianfu2, CHEN Dongdong2   

  1. (1.Department of Teaching Basic Courses,Armed Police Academy,Langfang 065000,China;
    2.State Key Laboratory of Supramolecular Structure and Materials,
    College of Chemistry,Jilin University,Changchun 130012,China)
  • Received:2013-12-06 Revised:2013-12-18 Published:2014-09-04 Online:2014-09-04

Abstract: The prevention of hospital-acquired infection attributable to indwelling urethral catheter use has recently received increased attention. For controlled release of antibacterial drugs, antibacterial films with a thickness less than 500 nm on urethral catheter were directly constructed by layer-by-layer deposition of poly(allylamine hydrochloride) and dextran(PAH-D) microgels with hyaluronic acid(HA). PAH-D/HA multilayer films can load negatively charged antibacterial drugs such as ceflriaxone sodium(CTX) in 2 min based on electrostatic interaction between PAH-D microgels and CTX molecules and then release them in 3 h in physiological saline. Direct deposition of microgel films and incorporation of CTX endow the multilayer micro films with an effective antibacterial performance.

Key words: Layer-by-layer assembly, Antibacterial, Microgel, Urethral catheter

CLC Number: