Application of Atomic Force Microscopy Based Single Molecule Force Spectroscopy in Biological Research

doi:10.3724/SP.J.1095.2013.20210

Chinese Journal of Applied Chemistry

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Application of Atomic Force Microscopy Based Single Molecule Force Spectroscopy in Biological Research

LI Hongying¹, GU Ningyu^1*, TANG Jilin^2*

(1.Department of Chemistry,Nanchang University,Nanchang 330031,China;
2.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China)

Received:2012-05-22 Revised:2012-07-05 Published:2012-12-10 Online:2012-12-10
Contact: Jilin Tang

Abstract

Abstract: Atomic force microscopy(AFM) is widely used in biological research, AFM based single molecule force spectroscopy can be applied to study the intramolecular and intermolecular interactions of biomolecules at the single-molecule and single-cell levels. In this paper, we present the latest progress of AFM based single molecule force spectroscopy in biomolecular interaction, protein unfolding, cell surface biomolecules, cell mechanical properties and single molecule force spectroscopy imaging.

Key words: atomic force microscopy, single molecule force spectroscopy, protein, cell

CLC Number:

O652.2

LI Hongying1, GU Ningyu1*, TANG Jilin2*. Application of Atomic Force Microscopy Based Single Molecule Force Spectroscopy in Biological Research[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.20210.

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Application of Atomic Force Microscopy Based Single Molecule Force Spectroscopy in Biological Research

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