Research Progress on Bioinspired Organs⁃on⁃Chips

doi:10.19894/j.issn.1000-0518.210446

Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (1): 18-34.DOI: 10.19894/j.issn.1000-0518.210446

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Research Progress on Bioinspired Organs⁃on⁃Chips

SUN Ling-Yu,GUO Jia-Hui,WANG Yu,XU Dong-Yu,ZHAO Yuan-Jin()

State Key Laboratory of Bioelectronics，School of Biological Science and Medical Engineering，Southeast University，Nanjing 210096，China

Received:2021-09-01 Accepted:2021-10-08 Published:2022-01-01 Online:2022-01-10
Contact: Yuan-Jin ZHAO
About author:yjzhao@seu.edu.cn
Supported by:
the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060);Shenzhen Fundamental Research Program(JCYJ20190813152616459)

Abstract

Abstract:

In the long process of evolution， nature has created numerous natural materials with excellent properties， which provides inspiration for the design and fabrication of artificial materials， as well as the development of related disciplines. With the advances in material science and manufacturing technology， bio-inspired materials are attracting extensive research and thus experiencing a rapid development. Based on elaborate morphology and component design， bioinspired materials have acquired diverse functions such as self-adaptation， self-healing， self-cleaning， fog collection， etc. Up to date， the bioinspired materials with extraordinary performances have demonstrated practical values in medicine， aerospace， biomedical field， daily life， and so on. In particular， the bioinspired materials could serve as biological scaffolds for cell culture and be further integrated into microfluidic chips to construct organ-on-chips systems. Compared with traditional cell experiments and animal models， the organ-on-chips platform is more appropriate for drug screening and disease model research， which could be attributed to the advantages of miniaturization， low consumption and more physiological-like environment. In this review， after introducing the fabrication method， we present the specific functions or features of the derived bioinspired materials. The focus of this review is concentrated on the integration of bioinspired materials into organ-on-chips and their applications. Finally， the challenges and opportunities of current organ-on-chips are also prospected.

Key words: Bioinspired, Cell culture, Organ-on-a-chip, Microfluidics, Drug screening

CLC Number:

O631

SUN Ling-Yu, GUO Jia-Hui, WANG Yu, XU Dong-Yu, ZHAO Yuan-Jin. Research Progress on Bioinspired Organs⁃on⁃Chips[J]. Chinese Journal of Applied Chemistry, 2022, 39(1): 18-34.

Figures/Tables 9

Fig.1 （a） Schematic diagram and the formation process of adhesive disc-like microparticles from microfluidics［17］. （b） Scheme and fabrication of helical microfibers from microfluidics with different flow rates［20］. （c） Bright field images of hierarchical photonic crystal films on different shapes of substrates via self-assembly at gas-liquid interface［23］. （d） Adhesive and self-reporting feature of structural color hydrogel patches replicated from self-assembled colloidal crystal templates［24］

Fig.2 （a） Fluorescent images showing the alignment of cardiomyocytes on structural color hydrogels with different concave and convex side values［58］. （b） Inverse opal film-integrated heart-on-a-chip and the structural color variation during film deformation process driven by cardiomyocytes［60］.. （c） Fluorescent images of cardiomyocytes cultured on an inverse opal microparticle and its structural color change under the actuation of cardiomyocytes［62］

Fig.3 （a） Schematic diagram and optical image of a breathable human lung-on-a-chip［66］. （b） A lung-on-a-chip integrated with inverse opal-structured hydrogel scaffold， and the viability comparison between human alveolar epithelial cells that cultured in the chip without or with breathing［67］

Fig.4 （a） Simplified scheme of neurovascular unit and BBB-brain parenchyma-BBB device （i）， optical photograph showing the design of the desired brain chip （ii） and fluorescent 3D reconstruction of the brain tissue cultured in the chip （iii）［72］. （b - c） Construction of a human BBB chip using multiple cells derived from induced pluripotent stem cells［73］

Fig.5 A liver-on-a-chip based on responsive scaffolds with responsive feature and its function evaluation［79］：（a） Schematic diagram of the liver-on-a-chip. （b） Optical image of the inverse opal scaffold-integrated liver-on-a-chip. （c - e） Data statistics showing the albumin secretion （c）， urea synthesis （d） and cytochrome P450 expression level （e） in different groups， respectively

Fig.6 （a） Design of a renal vascular-tubular unit chip. （b， c） The chip was composed of a parallel-channel bottom layer and a parallel-channel （b） or a grid-channel （c） top layer［85］

Fig.7 （a） Channel design of a multi-organ chip for simulating lung cancer metastasis to the brain， bone and liver［92］. （b） The chip fabrication （i） and optical photograph （ii） of a gut-liver-on-a-chip［94］

Fig.8 Assessment of environmental pollutants based on a lung-on-a-chip with alveolar-capillary interface［100］

Fig.9 （a–c） Heart-on-a-chip based on micropatterned structural color hydrogel film and its application for drug evaluation［58］. （d–f） Structural color microfiber-integrated multichannel heart-on-a-chip for gradient drug testing［63］

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Research Progress on Bioinspired Organs⁃on⁃Chips

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