Advances of NIR-Ⅱ-Triggered Photodynamic Therapy in Overcoming Tumor Hypoxia Environment

doi:10.19894/j.issn.1000-0518.240061

Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (7): 925-936.DOI: 10.19894/j.issn.1000-0518.240061

• Review • Next Articles

Advances of NIR-Ⅱ-Triggered Photodynamic Therapy in Overcoming Tumor Hypoxia Environment

Yi-Qian YANG¹^,²^,³, Xiao-Xia YAN¹(), Hao PENG²^,³(), Ai-Guo WU²^,³, Fang YANG²^,³()

^1.Department of Chemistry，Shanghai University，Shanghai 200444，China
^2.Laboratory of Advanced Theranostic Materials and Technology，Ningbo Institute of Materials Technology and Engineering，Chinese Academy of Sciences，Ningbo 315201，China
^3.Advanced Energy Science and Technology Guangdong Laboratory，Huizhou 516000，China

Received:2024-02-29 Accepted:2024-04-19 Published:2024-07-01 Online:2024-08-03
Contact: Xiao-Xia YAN,Hao PENG,Fang YANG
About author:yangf@nimte.ac.cn
penghao@nimte.ac.cn
xxyan@shu.edu.cn
Supported by:
the Youth Innovation Promotion Association, Chinese Academy of Sciences(2022301);Ningbo 3315 Innovative Talent Project(2018-05-G)

Abstract

Abstract:

Photodynamic therapy has been widely used in tumor treatment for decades because of its non-invasive nature， temporal and spatial selectivity， and lower side effects. It employs photosensitizers， light and oxygen molecules to selectively induce apoptosis and necrosis of target cells through photosensitizer-mediated generation of free radicals leading to oxidative damage. However， the drawbacks of conventional photosensitizers， limited tissue penetration of light， molecular oxygen dependence， and inherent tumor barriers against treatment have largely limited the efficacy of photodynamic therapy. Various novel photosensitizers under near-infrared light excitation have been developed in recent years to overcome these barriers and enable photodynamic therapy for deep tumors. Concerning the oxygen-deprived environment of deep tumor tissues， it is helpful to optimize the efficacy of tumor inhibition through strategies that improve， exploit the hypoxic tumor microenvironment. In this review， on the basis of elucidating the working mechanism of photodynamic therapy， we systematically summarize and discuss the recent advances in the strategy of the second near-infrared window-triggered photodynamic therapy in overcoming tumor hypoxia in the past five years， as well as the prospect of its development.

Key words: Nanomaterials, Photodynamic therapy, Tumor therapy, Second near-infrared window, Hypoxia

CLC Number:

O644

Yi-Qian YANG, Xiao-Xia YAN, Hao PENG, Ai-Guo WU, Fang YANG. Advances of NIR-Ⅱ-Triggered Photodynamic Therapy in Overcoming Tumor Hypoxia Environment[J]. Chinese Journal of Applied Chemistry, 2024, 41(7): 925-936.

Figures/Tables 8

Fig.1 Strategic design of NIR-?Ⅱ??-triggered photodynamic therapy in conquering the tumor hypoxia environment

Fig.2 Principles of photodynamic reactions

Fig.3 （A） 1O2 production of different samples；（B） 1O2 production after irradiation in different hypoxic conditions［35］

Fig.4 （A） Schematic illustration of the defect engineering of CoMo-LDH nanosheets； Identification of 1O2 generation by measuring the absorbance of ABDA in the presence of the CoMo-LDH nanosheets under different environments （B） and ESR spectra of TEMP for the CoMo-LDH nanosheets in different cases （C）［48］

Fig.5 The production of 1O2 and related flow cytometry data after different treatments［54］

Fig.6 （A） Schematic illustration of all-in-one nanoplatform containing MnO2/Ag3SbS3；（B） GSH depletion and O2 generation under different treatments［59］

Fig.7 （A） Schematic illustration of mechanism of CMS@GOx for PTT/PDT/CDT/starvation therapy；（B） The generation of dissolved O2 in CMS aqueous solution without and with H2O2 addition；（C） H2O2 generation in CMS@GOx solution arising from the addition of different concentrations of glucose：（a） 0 L，（b） 2×10-3 L，（c） 4×10-3 L，（d） 8×10-3 L；（D） Generation of ·OH over CMS or CMS@GOx under different treatments［65］

Fig.8 Illustration for synergistic NO therapy and phototherapy［74］

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Advances of NIR-Ⅱ-Triggered Photodynamic Therapy in Overcoming Tumor Hypoxia Environment

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