Preparation and Release Behavior of Progesterone Nano Micelles in Vitro

doi:10.11944/j.issn.1000-0518.2020.11.200239

Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (11): 1340-1342.DOI: 10.11944/j.issn.1000-0518.2020.11.200239

• Communications • Previous Articles

Preparation and Release Behavior of Progesterone Nano Micelles in Vitro

QI Yanxin^a,b, HUANG Yubin^b*, JIN Ningyi^a,c*

^aMedical College,Yanbian University,Yanji,Jilin 133002,China;
^bState Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;
^cInstitute of Military Veterinary Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Changchun 130112,China

Received:2020-08-10 Revised:2020-08-25 Accepted:2020-09-18 Published:2020-11-01 Online:2020-11-04
Contact: JIN Ningyi, professor; Tel/Fax:0431-86985929; E-mail:ningyik@126.com; Research interests:biotechnology research and development
Co-corresponding author:HUANG Yubin, professor; Tel/Fax:0431-85262769; E-mail:ybhuang@ciac.ac.cn; Research interests:polymer design and application
Supported by:
Supported by the National Natural Science Foundation of China(No.51673188, No.51903233, No.21975246)

Abstract

Abstract: To prepare new controlled-release progesterone nano micelles, polyethylene glycol-polypropylene glycidyl ether polymer (PEG-PAGE), a diblock degradable polymer carrier, micelles carring progesterone were assembled in water. The drug load and encapsulation ratio under different conditions were investigated and the optimal proportion was selected for the in vitro release study. The results show that the micelles can carry progesterone with a drug load of 4.26% and the encapsulation efficiency of 21.30%. The nano micelles can effectively prolong the release of progesterone. This research is an experimental and technical reference for the development of similar dosage forms of steroid hormones.

Key words: polymer, polyethylene glycol-polypropylene glycidyl ether, progesterone, micellar

CLC Number:

O631

QI Yanxin, HUANG Yubin, JIN Ningyi. Preparation and Release Behavior of Progesterone Nano Micelles in Vitro[J]. Chinese Journal of Applied Chemistry, 2020, 37(11): 1340-1342.

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Preparation and Release Behavior of Progesterone Nano Micelles in Vitro

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