以喹唑啉酮为核心高选择高灵敏识别次氯酸根离子的荧光探针的合成及应用

doi:10.19894/j.issn.1000-0518.210151

摘要/Abstract

摘要： 为了高选择、有针对性地荧光识别次氯酸根离子(ClO^-),以喹唑啉酮(11H-吡啶并[2,1-b]喹唑啉-11-酮)为核心组块,与喹啉酮醛拼接作为荧光团,以酰腙为反应位点,设计合成了一种荧光分子(E)-11-氧代-N'-((2-氧代-1,2-二氢喹啉-3-基)亚甲基)-11H-吡啶并[2,1-b]喹唑啉-6-碳酰肼(XJQZL)。 XJQZL具有优良的荧光性能:在较宽的pH值范围内具有较优良的稳定性、较高的荧光量子产率(0.469)和大的斯托克斯位移(128 nm)。 XJQZL能高选择性荧光识别ClO^-,快速(响应时间30 s)、灵敏(灵敏度为1.23×10⁵ L/mol),检测限为1×10^-7 mol/L,猝灭效率高达81.6%,XJQZL荧光检测ClO^-的pH值范围较宽 (pH=5~13),抗干扰性强。 XJQZL能应用于实际水样中高选择、定性定量荧光检测ClO^-。

关键词: 喹唑啉酮, 喹啉酮醛, 荧光探针, 次氯酸根离子

Abstract: For highly selective and targeted fluorescent identification of ClO^-, a novel fluorescence molecule (E)-11-oxo-N'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)-11H-pyrido [2,1-b]quinazole phenoline-6-carbohydrazide (XJQZL) was designed and synthesized, in which the core block tricycloquinazolinone [11H-pyrido[2,1-b]quinazolin-11-one] spliced with quinolinone aldehyde was used as the fluorophore and acylhydrazone as the reaction position. It is found that XJQZL has excellent fluorescence properties: good stability in a wide range of pH, high fluorescence quantum yield (0.469) and large Stokes shift (128 nm). XJQZL exhibits highly selective fluorescent recognition of ClO^- within 30 s. The detection limit and sensitivity are 1×10^-7 mol/L and 1.23×10⁵ L/mol, respectively. The fluorescent detection of ClO^- using XJQZL can be in a wide range of pH (pH=5~13). XJQZL has a high quenching efficiency of 81.6% and strong anti-interference. XJQZL can be applied to qualitatively and quantitatively confirm ClO^- in actual water samples.

Key words: Quinazolinone, Quinolinone aldehyde, Fluorescence probe, Hypochlorite

中图分类号:

O626

张成路, 暴金迪, 于丰铭, 董文静, 张洋, 宫荣庆, 张彦朋, 张璐. 以喹唑啉酮为核心高选择高灵敏识别次氯酸根离子的荧光探针的合成及应用[J]. 应用化学, 2021, 38(8): 986-994.

ZHANG Cheng-Lu, BAO Jin-Di, YU Feng-Ming, DONG Wen-Jing, ZHANG Yang, GONG Rong-Qing, ZHANG Yan-Peng, ZHANG Lu. Synthesis and Application of a Fluorescence Probe with Quinazolinone as the Core Block for Highly Selective and Sensitive Detection of Hypochlorite Ion[J]. Chinese Journal of Applied Chemistry, 2021, 38(8): 986-994.

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