中华医学超声杂志

应用化学 ›› 1996, Vol. 0 ›› Issue (1): 14-17.

• 研究论文 • 上一篇    下一篇

3-N,N-二甲基-1,3-丙二胺/冰醋酸催化下的Knoevenagel缩合反应

岳国仁, 王建华, 张正   

  1. 南京大学化学系 南京 210008
  • 收稿日期:1995-04-27 修回日期:1995-10-12 出版日期:1996-02-10 发布日期:1996-02-10
  • 基金资助:
    煤炭部青年科学基金

Knoevenagel Condensation Catalyzed by N,N-Dimethyl-1,3-Propanediamine

Yue Guoren, Wang Jianhua, Zhang Zheng   

  1. Department of Chemistry, Nanjing University, Nanjing 210008
  • Received:1995-04-27 Revised:1995-10-12 Published:1996-02-10 Online:1996-02-10

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摘要： 对硝基苯磺酰基乙腈与芳香醛在3-N,N-二甲基-1,3-丙二胺(DPA)/冰醋酸催化下可顺利地发生Knoevenagel缩合反应,生成2-(4-硝基苯磺酰基肉桂腈类化合物,产率83%～98%.但与水杨醛反应生成的产物是六元环内酯,其结构经元素分析、IR、1HNMR和MS确证。

关键词: 二甲基丙二胺, 催化, 对硝基苯磺酰基乙腈, Knoevenagel缩合反应

Abstract: N,N-Dimethyl-1,3-propanediamine(DPA) is a useful catalyst for Knoevenagel reaction.2-(4-Nitrophenyl sulfonyl)-cinnamonitriles(3a～k) were obtained by condensation of 4-nitrophenylsulfonylacetonitrile(1) with aromatic aldehydes(2a～k) in the presence of DPA.The yields ranged from 83%～98%.However,the condensation between 2-hydroxybenzaldehyde and 4-nitrophenylsulfonyl-acetonitril gave a six-memberod lactone(31).The structure of compounds 3a～1 was confirmed by elemental analysis,IR,1H NMR and MS.

Key words: dimethylpropanediamine(DPA), catalysis, nitrophenylsulfonylacetonitrile, Knoevenagel reaction

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