应用化学 ›› 1993, Vol. 0 ›› Issue (5): 108-109.

• 研究简报 • 上一篇    下一篇

微波快速烷基化合成α-氨基酸

邓润华, 宓爱巧, 蒋耀忠   

  1. 中国科学院成都有机化学研究所 610041 成都
  • 收稿日期:1992-12-25 修回日期:1993-05-21 出版日期:1993-10-10 发布日期:1993-10-10
  • 基金资助:
    国家自然科学基金资助课题

SYNTHESIS OF α-AMINO ACID VIA RAPID ALKYLATION UNDER MICROWAVE

Deng Runhua, Mi Aiqiao, Jiang Yaozhong   

  1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, 610015 Chengdu
  • Received:1992-12-25 Revised:1993-05-21 Published:1993-10-10 Online:1993-10-10

摘要: 前文曾报道以固体K2CO3作为碱的固-液相转移催化条件下,醛亚胺的α-位能形成碳负离子,并顺利地进行烷基化反应,水解后生成α-氨基酸。 微波技术已用于一些化合物的合成反应。本文用微波技术进行相转移催化反应,以N-苯亚甲氨基乙酸甲酯为原料,分别与不同的卤化物反应,经水解生成不同的α-氨基酸。其特点是快速,只需1~2分钟,不需用溶剂,产率高。

关键词: 苯亚甲氨基乙酸甲酯, 氨基酸, 合成, 相转移催化, 烷基化, 水解, 微波

Abstract: Five α-amino acids were prepared by rapid alkylation without solvent under microwave and phase transfer catalysis. The alkylation lasted only for 1~2min. The α-amino acids were obtained by after hydrolysis. The overall yields were 43.6%~62.5%.

Key words: N-benzylidene glycinate, amino acid, synthesis microwave, phase transfer catalysis, alkylation, hydrolysis