应用化学 ›› 1989, Vol. 0 ›› Issue (5): 44-46.
• 研究简报 • 上一篇 下一篇
杨宝康, 蒋彩花, 胡秉方
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Yang Baokang, Jiang Caihua, Hu Bingfang
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摘要： 环氧化合物,尤其是2,3-环氧羧酸类化合物既是一类重要的有机合成中间体,又是一类很有前途的生物活性物质,并广泛存在于自然界中,与生物体内的生理生化过程紧密相连[1]。
关键词: 2,3-环氮羧酸-对-溴苯甲酰甲基酯, 抗菌活性, 农药, 合成
Abstract: Some novel p-bromophenacyl-2,3-oxirane carboxylic esters were synthesized by Darzen′s condensation and esterification. The compounds were characterized by IR, 1H NMR spec-troscopy and clemental analysis. The antifungal activity of the compounds in vitro has been determined. It is foundthat, in general, the antifungal activity against Pellicularia Sasakii was higher than thatagainst Macyodhane Kawatasukai and Gibberella Zeae. p-Bromophenacyl-3, 3-pentamethy1ene-2, 3-oxiranepropanoic ester(2), p-bromophenacyl-3-(β-naphthyl)-2,3-oxiranepropanoicester(11)were the most effective which can completely inhibite the mycelial growth of P. Sasakil, M. Kawatsukai in amount of 100 ppm. p-Bromophenacyl-5-methyl-2,3-oxiranehexanoic ester(1) and p-bromophenacyl-3-(p-chlorophenyl)-2, 3-oxiranebutanoic ester(7) were highlyactive against P. Sasakii.
Key words: p-Bormophenacy1-2, 3-oxirane carboxylic esters, Antifungal activity, Synthesis, Pesticide
杨宝康, 蒋彩花, 胡秉方. 2,3-环氧羧酸-对-溴苯甲酰甲基酯的合成及其抗菌活性[J]. 应用化学, 1989, 0(5): 44-46.
Yang Baokang, Jiang Caihua, Hu Bingfang. SYNTHESIS OF p-BROMOPHENACYL-2,3-OXIRANE CARSOXYLATE AND ITS ANTIFUNGAL ACTIVITY[J]. Chinese Journal of Applied Chemistry, 1989, 0(5): 44-46.
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