双吲哚烷基类化合物在无催化剂和无溶剂条件下的高效合成

doi:10.3724/SP.J.1095.2014.30434

摘要/Abstract

摘要： 在不加催化剂和溶剂条件下，由取代吲哚和取代苯甲醛合成15个已知的双吲哚烷基化合物，反应无溶剂污染，反应条件温和，收率为65%~91%。讨论了反应速度和取代基的关系，探讨了缩合反应的机理。并用1H NMR、13C NMR、IR和HRMS等技术手段确定了产物结构。

关键词: 醛, 双吲哚烷基类化合物, 吲哚

Abstract: Without the addition of catalysts and solvents, 15 known bis(indolyl)alkane compounds were synthesized under mild conditions from substituted indoles and substituted benzaldehydes in 65%~91% yields. The mechanism of this condensation reaction was discussed and the relationship between reaction speed and substituent groups was described. All the compounds synthesized were confirmed by 1H NMR, 13C NMR and IR analysis.

Key words: Aldehyde, bisindolylalkane, indole

中图分类号:

O623.1

刘雄伟, 潘博文, 郭丰敏, 曹煜, 刘雄利, 周英. 双吲哚烷基类化合物在无催化剂和无溶剂条件下的高效合成[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30434.

LIU Xiongwei1, PAN Bowen1, GUO Fengmin1, CAO Yu2, LIU Xiongli1, ZHOU Ying1*. Efficient Synthesis of Bis(indolyl)methanes Under Solvent-free and Catalyst-free Conditions[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30434.

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