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应用化学

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鲁米诺-过氧化氢-纳米银化学发光体系测定药物中的对乙酰氨基酚

樊雪梅1,2*,王书民1,崔效伟1   

  1. (1.商洛学院化学与化学工程系 商洛 726000;2.商洛市材料科学工程研究院 商洛 726000)
  • 收稿日期:2013-01-25 修回日期:2013-04-03 出版日期:2014-01-10 发布日期:2014-01-10
  • 通讯作者: 樊雪梅,讲师; Tel/Fax:0914-2986027; E-mail:fanxuemei527@163.com; 研究方向:光分析化学
  • 基金资助:
    陕西省尾矿资源综合利用重点实验室(商洛学院)及陕西省科技统筹创新工程计划(2012KTDZ020202)项目资助

Determination of Acetaminophen in Pharmaceuticals by Luminol-H2O2-Silver Nanoparticle Chemiluminescence System

FAN Xuemei1,2*, WANG Shumin1, CUI Xiaowei1   

  1. (1.Department of Chemistry and Chemical Engineering,Shuoluo College,Shangluo 726000,China;
    2.Shangluo Engineering of Materials Science and Research Institute,Shangluo 726000,China)
  • Received:2013-01-25 Revised:2013-04-03 Online:2014-01-10 Published:2014-01-10

摘要: 碱性条件下,对乙酰氨基酚对鲁米诺-过氧化氢-纳米银化学发光体系有较强的抑制作用,基于此,结合流动注射技术,建立了测定对乙酰氨基酚的新方法。 研究了影响化学发光强度的各种因素,并初步探讨了可能的发光机理。 在最佳实验条件下,对乙酰氨基酚浓度在2.0×10-8~1.0×10-4 mol/L范围内与相对发光强度呈线性关系,检出限(3σ)为4.0×10-9 mol/L。 对1.0×10-7 mol/L的对乙酰氨基酚平行测定9次,相对标准偏差为2.6%。 该法用于片剂中扑热息痛含量的测定,结果令人满意。

关键词: 化学发光, 纳米银, 鲁米诺, 对乙酰氨基酚

Abstract: A novel method for the determination of acetaminophen was developed based on its inhibition effect on the luminol-H2O2-silver nanoparticle chemiluminescence system. Various factors influencing the chemiluminescence system were investigated and the possible mechanism was also studied. Under the optimum conditions, the linear range for the determination of acetaminophen is 2.0×10-8 to 1.0×10-4 mol/L with a detection limit of 4.0×10-9 mol/L. The relative standard deviation is 2.6% for 1.0× 10-7 mol/L acetaminophen solution in nine repeated measurements. The method was successfully applied to the determination of acetaminophen in pharmaceutical.

Key words: chemiluminescence, Ag nanoparticles, luminol, acetaminophen

中图分类号: 

 Chinese Journal of Applied Chemistry
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