应用化学 ›› 2010, Vol. 27 ›› Issue (09): 1105-1107.DOI: 10.3724/SP.J.1095.2010.90797

• 研究简报 • 上一篇    下一篇

新型吡啶基吡唑酰胺类化合物的合成

郑毅,王俊芳,张应鹏*,杨云裳   

  1. (兰州理工大学石油化工学院 兰州 730050)
  • 收稿日期:2009-11-30 修回日期:2010-01-20 出版日期:2010-09-10 发布日期:2010-09-10
  • 通讯作者: 张应鹏,男,副教授; E-mail:yingpengzhang@126.com; 研究方向:有机合成
  • 基金资助:
    甘肃省自然科学基金(3ZS062-B25-017)资助项目

Synthesis of Novel Pyridyl-pyrazole-5-carboxylic Acid Amide Compounds

ZHENG Yi, WANG Jun-Fang, ZHANG Ying-Peng*, YANG Yun-Shang   

  1. (School of Petrochemical Engineering,Lanzhou University of Technology,Lanzhou 730050)
  • Received:2009-11-30 Revised:2010-01-20 Published:2010-09-10 Online:2010-09-10

摘要:

以2,3-二氯吡啶为起始原料,经过肼解、与马来酸二乙酯成环、卤代、氧化和水解得到关键中间体吡啶基吡唑甲酸,然后与二氯亚砜反应生成甲酰氯,最后与各种环氨作用生成吡啶基吡唑甲酰胺类化合物。

关键词: 吡啶基吡唑羧酸, 酰胺, 合成

Abstract:

Key intermediate pyridinyl-1H-pyrazole-5-carboxylic acid was synthesized from the reaction of 2,3-dichloropyridine with hydrazine, which was then treated with diethyl maleate, then esterified through halogenation, oxidation, hydrolysis. Carbonyl chloride was synthesized by dichloro sulfoxide, and pyridinyl-1H-pyrazole-5-carboxylic acid amide compounds were synthesized by carbonyl chloride reacting with corresponding ammonia.

Key words: pyridyl-pyrazolecarboxylic acid, amide, synthesis

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