应用化学 ›› 2016, Vol. 33 ›› Issue (11): 1245-1252.DOI: 10.11944/j.issn.1000-0518.2016.11.160327

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纳米酶及其分析检测应用研究进展

李俊容,沈爱国,胡继明()   

  1. 武汉大学化学与分子科学学院,生物医学分析教育部重点实验室 武汉 430072
  • 收稿日期:2016-08-17 接受日期:2016-09-21 出版日期:2016-11-01 发布日期:2016-11-01
  • 通讯作者: 胡继明
  • 基金资助:
    国家自然科学基金资助项目(81471696,21475100,41273093)

Research Progress of Nanozymes and Its Application in Analysis

LI Junrong,SHEN Aiguo,HU Jiming()   

  1. Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education),College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China
  • Received:2016-08-17 Accepted:2016-09-21 Published:2016-11-01 Online:2016-11-01
  • Contact: HU Jiming
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.81471696, No.21475100, No.41273093)

摘要:

在纳米材料基础上诞生的纳米酶推动了化学、材料学以及生物学等学科的发展。纳米酶克服了天然酶的许多缺点,如价格昂贵、易失活和储存条件要求苛刻等,对生物传感、免疫分析、癌症诊断和治疗等领域产生了巨大的影响。 本论文主要介绍了迄今发现的纳米酶种类、纳米酶调控方式以及纳米酶在分析检测中的应用进展。 此外,针对纳米酶未来发展方向提出了一些思考和建议。

关键词: 纳米酶, 模拟酶, 催化, 生物传感

Abstract:

Nanozymes, developed on the basis of nanomaterials, have promoted the development of chemistry, materials science and biology. Nanozymes have overcome many drawbacks of natural enzymes, such as high cost, easy loss of activity and rigid storage requirements. Currently, nanozymes have had great impact on biosensing, immunoassay and cancer diagnosis. This review article mainly focuses on the categories of nanozymes, the methods to tailor the activity of nanozymes and the research progress in the analytical application of nanozymes. Furthermore, a few thoughts and suggestions have been made to the future development direction of nanozymes.

Key words: nanozymes, mimetics, catalysis, biosensing