Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (7): 976-986.DOI: 10.19894/j.issn.1000-0518.230402
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Guo-Ying GUO1, Mo-Xuan ZHAO1, Wen-Ting LIANG2, Tao GONG1,2(), Chuan DONG2()
Received:
2023-12-28
Accepted:
2024-04-03
Published:
2024-07-01
Online:
2024-08-03
Contact:
Tao GONG,Chuan DONG
About author:
dc@sxu.edu.cnSupported by:
CLC Number:
Guo-Ying GUO, Mo-Xuan ZHAO, Wen-Ting LIANG, Tao GONG, Chuan DONG. Preparation and Anti‑Cancer Properties of Gold Nanosphere‑Graphene Oxide Nanodrug Carriers[J]. Chinese Journal of Applied Chemistry, 2024, 41(7): 976-986.
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URL: http://yyhx.ciac.jl.cn/EN/10.19894/j.issn.1000-0518.230402
Fig. 5 Temperature change curves (A) and corresponding infrared thermal images (B) of different components of GO-AuNP under NIR irradiation(2.0 W/cm2); Temperature variation graph of GO-AuNP at different concentrations under NIR irradiation(2.0 W/cm2) (C); Temperature variation graph of GO-AuNP under different power NIR irradiation (D); Temperature cycle variation graph of GO-AuNP (E)
Fig.6 (A) The adsorption kinetic curves of GO-AuNP on DOX; Linear fitting graphs of the dynamic model for Lagergren's pseudo-first-order (B) and Ho's pseudo-second-order (C)
Lagergern's pseudo?first?order kinetic model | Ho's pseudo?second?order kinetic model | ||||
---|---|---|---|---|---|
qe/(mg·g-1) | K1/h-1 | R2 | qe/(mg·g-1) | K2/(g·mg-1·min-1) | R2 |
24.64 | 0.027 75 | 0.987 6 | 41.07 | 0.001 700 | 0.999 7 |
Table 1 Parameters related to the drug delivery kinetics of GO?AuNP to DOX
Lagergern's pseudo?first?order kinetic model | Ho's pseudo?second?order kinetic model | ||||
---|---|---|---|---|---|
qe/(mg·g-1) | K1/h-1 | R2 | qe/(mg·g-1) | K2/(g·mg-1·min-1) | R2 |
24.64 | 0.027 75 | 0.987 6 | 41.07 | 0.001 700 | 0.999 7 |
Fig.7 The isothermal adsorption curve of GO-AuNP on DOX (A); Linear fitting graphs with the Langmuir adsorption isotherm model (B) and Freundlich adsorption isotherm model (C)
Langmuir isotherm model | Freundlich isotherm model | ||||
---|---|---|---|---|---|
qm/(mg·g-1) | KL/(mg·mL-1) | R2 | n | Kf /(mL·g-1) | R2 |
458.8 | 0.042 80 | 0.887 0 | 515.5 | 1.011 | 0.995 1 |
Table 2 Parameters related to the drug isothermal adsorption of GO?AuNP to DOX
Langmuir isotherm model | Freundlich isotherm model | ||||
---|---|---|---|---|---|
qm/(mg·g-1) | KL/(mg·mL-1) | R2 | n | Kf /(mL·g-1) | R2 |
458.8 | 0.042 80 | 0.887 0 | 515.5 | 1.011 | 0.995 1 |
Fig.8 (A) Cumulative release of DOX from GO-AuNP@DOX at pH=5.3 and 7.4; (B) Cumulative release of DOX from GO-AuNP@DOX with and without NIR irradiation at pH=5.3
Fig.11 (a) Thermal imaging of tumor sites treated with PBS and GO-AuNP@DOX under NIR irradiation (808 nm, 2.0 W/cm2) for 0~5 min; (B) Tumor tissue images of mice under different treatment conditions
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