Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (6): 726-732.DOI: 10.11944/j.issn.1000-0518.2020.06.190332

• Full Papers • Previous Articles    

Determination of Ofloxacin in Medicine via Poly(p-aminobenzene sulfonic acid)/Graphene Electrochemical Modified Electrode

SI Xiaojinga,ZHU Wenjinga,LI Xianga,LI Lic,CHEN Zichaob*(),DING Yapingc*()   

  1. aDepartment of Food Science,Shanghai Business School,Shanghai 200235,China
    bExperimental Center,Shandong University of Traditional Chinese Medicine,Jinan 250355,China
    cDepartment of Chemistry,Shanghai University,Shanghai 200444,China
  • Received:2019-12-12 Accepted:2020-03-26 Online:2020-06-01 Published:2020-06-08
  • Contact: CHEN Zichao,DING Yaping
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21671132), the Shandong Provincial Key Research and Development Program(No.2019GSF108253), and the Undergraduate Specialty Construction Project of Shanghai Municipal Universities(Sixth batch)


A simple, rapid and sensitive electrochemical analysis method with a poly(p-aminobenzene sulfonic acid)/graphene modified glassy carbon electrode (pABSA/GR/GCE) for the determination of ofloxacin (OFL) is established based on GR nanomaterials and cyclic voltammetry (CV) in this study. Compared with the glassy carbon electrode, the peak current of OFL increases significantly using pABSA/GR/GCE. Under optimized experimental conditions, the pABSA/GR/GCE shows a good linear relationship with the concentration of OFL in the range of 1~600 μmol/L and a detection limit (S/N=3) of 0.33 μmol/L. The pABSA/GR/GCE is easy to be prepared with good reproducibility and stability. It has been used in the determination of ofloxacin eye drops with satisfactory results.

Key words: graphene, p-aminobenzene sulfonic acid, modified electrode, ofloxacin