Recent Progress on the Construction of Chiral 3-Amino-2-oxindoles Skeleton with Isatin-Derived Ketimines as Reactants

doi:10.11944/j.issn.1000-0518.2019.12.190170

Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (12): 1343-1360.DOI: 10.11944/j.issn.1000-0518.2019.12.190170

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Recent Progress on the Construction of Chiral 3-Amino-2-oxindoles Skeleton with Isatin-Derived Ketimines as Reactants

ZHANG Junwei^a,WU Hao^a,CHEN Zhe^a,JIN Ying^b^*(),JIANHG Yingzi^a^*()

^aDepartment of Pharmacy,Yanbian University,Yanji,Jilin 130000,China
^bDepartment of Pharmacy,Jilin Medical University,Jilin,Jilin 132013,China

Received:2019-06-12 Accepted:2019-09-05 Published:2019-12-01 Online:2019-12-10
Contact: JIN Ying,JIANHG Yingzi
Supported by:
Supported by the National Natural Science Foundation of China(No.2112055), the Department of Education of Jilin Province(No.JJKH20180835KJ), and the Health Department of Jilin Province(No.2017J104)

Abstract

Abstract:

The chiral 3-amino-2-oxindole skeletons are widely present in many drug molecules and natural products, and show high medicinal value. The asymmetric reaction involving of isatin-derived ketimines provides a direct access to chiral 3-amino-2-oxindole derivatives. In this paper, the recent progress on the asymmetric aza-Henry, cyclization and other asymmetric reactions for the construction of 3-amino-2-oxindoles skeleton with isatin-derived ketimines is reviewed and the future development is prospected.

Key words: isatin-derived ketimines, asymmetric, aza-henry, cyclization, 3-amino-2-oxindole

ZHANG Junwei,WU Hao,CHEN Zhe,JIN Ying,JIANHG Yingzi. Recent Progress on the Construction of Chiral 3-Amino-2-oxindoles Skeleton with Isatin-Derived Ketimines as Reactants[J]. Chinese Journal of Applied Chemistry, 2019, 36(12): 1343-1360.

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Recent Progress on the Construction of Chiral 3-Amino-2-oxindoles Skeleton with Isatin-Derived Ketimines as Reactants

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