Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (11): 1236-1248.DOI: 10.11944/j.issn.1000-0518.2020.11.200151

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Advances in Synthetic Methods of (R)-α-Lipoic Acid

HAN Xiua, KANG Chuanqingb*   

  1. aCollege of Chemistry,Sichuan University,Chengdu 610000,China;
    bChangchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
  • Received:2020-05-19 Revised:2020-06-28 Accepted:2020-07-23 Online:2020-11-01 Published:2020-11-04
  • Contact: KANG Chuanqing, professor; Tel:0431-85262291;; Research interests:asymmetric synthesis, synthesis, self-assembly, and bioactivity of functional organic molecules

Abstract: The methods for the effective synthesis of (R)-α-lipoic acid have been widely investigated since (R)-α-lipoic acid can be widely used for the treatment of diabetes and diabetic complications. It is also extensively used in health care products. Therefore, asymmetric synthesis of (R)-α-lipoic acid has attracted broad interests from the community of both academia and industry. To date, the reported routes for the synthesis of (R)-α-lipoic acid include asymmetric synthesis catalyzed by the enzymatic and chemical catalysts, chiral resolution, and chiral substrate-controlled synthesis. Based on this classification, this paper summarizes the advances of the methods for asymmetric synthesis of (R)-α-lipoic acid and predicts future prospects.

Key words: lipoic acids, chiral resolution, asymmetric synthesis

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