Application of Quantum Dots in Biological Detection

doi:10.3724/SP.J.1095.2014.30457

Chinese Journal of Applied Chemistry

• Review • Previous Articles Next Articles

Application of Quantum Dots in Biological Detection

CHU Congbo¹, SHAN Yuping^2*, WANG Hongda^2*

(1.Jilin Province Water Resource and Hydropower Consultative Company,Changchun 130021,China;
2.State Key laboratory of Electroanalytical Chemistry,Changchun Institute of
Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China)

Received:2013-09-09 Revised:2013-11-07 Published:2014-04-10 Online:2014-04-10

Abstract

Abstract: During the past ten years, the application of semiconductor nanocrystal material-quantum dots has displayed an increased tendency in scientific and industrial production fields, and a broad research is developed from materials science to biological applications. The application of quantum dots has substantially impacted on many research areas, such as biological imaging, phototherapy, drug/gene delivery, and solar cell. It is a key point to control the interactions between quantum dots and cell through adjusting surface properties of quantum dots. As the potential cytotoxicity of quantum dots arise, nanotoxicity becomes an important indicator of nanomaterials security assessment, and scientists pay more attention to the research of their potential toxicity. In this review we overviewed the properties of quantum dots, the applications in cell biology and the cytotoxicity research in biomedicine related field. Moreover, the future prospects for applications of quantum dots were briefly presented.

Key words: Quantum dots, biological application, fluorescence label, cytotoxicity

CLC Number:

O652

CHU Congbo1, SHAN Yuping2*, WANG Hongda2*. Application of Quantum Dots in Biological Detection[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30457.

References

[1] Li F,Chen H,Ma L,et al. Insights into Stabilization of a Viral Protein Cage in Templating Complex Nanoarchitectures:Roles of Disulfide Bonds[J]. Small,2013,doi:10.1002/smll.201300860.

[2] Haldar K K,Sen T,Patra A. Metal Conjugated Semiconductor Hybrid Nanoparticle-Based Fluorescence Resonance Energy Transfer[J]. J Phys Chem C, 2010,114:4869-4874.

[3] Weaver J E,Dasari M R,Datar A,et al. Investigating Photoinduced Charge Transfer in Carbon Nanotube-Perylene-Quantum Dot Hybrid Nanocomposites[J]. ACS Nano,2010,4:6883-6893.

[4] Louie A. Multimodality Imaging Probes:Design and Challenges[J]. Chem Rev,2010,110:3146-3195.

[5] Zhu H,Song N,Lian T. Charging of Quantum Dots by Sulfide Redox Electrolytes Reduces Electron Injection Efficiency in Quantum Dot Sensitized Solar Cells[J]. J Am Chem Soc,2013,135:11461-11464.

[6] Justo Y,Goris B,Kamal J S,et al. Multiple Dot-in-Rod PbS/CdS Heterostructures with High Photoluminescence Quantum Yield in the Near-Infrared[J]. J Am Chem Soc,2012,134:5484-5487.

[7] Bigall N C,Parak W J. Polymer Coating of Quantum Dots for Excellent Colloidal Stability[J]. Protocal Excahnge,2012,doi:10.1038/protex.2012.043.

[8] ZHANG Chuanzhou，TAN Hui，MAO Yan,et al. Synthesis and Properties of Luminescent Carbon Dots and Its Applications[J]. Chinese J Appl Chem,2013,30(4):367-372(in Chinese).

张川洲,谭辉,毛燕，等. 发光碳量子点的合成、性质和应用[J]. 应用化学，2013,30(4):367-372.

[9] WU Yuqin,CHEN Jinlong. Sensitive Detection of L-Cysteine by Using Blue Luminescent Gold Quantum Dots[J]. Chinese J Appl Chem,2013,30(2):225-231(in Chinese).

吴玉芹,陈金龙. 水溶性发光金量子点灵敏检测L-半胱氨酸[J]. 应用化学,2013,30(2):225-231.

[10] YIN Pengfei,GONG Huiping,LIU Zhengqing,et al. Determination of Jatrorrhizine Hydrochloride by Core-shell CdTe/CdS Quantum Dots with Fluorescence Quenching Method[J]. Chinese J Appl Chem,2012,29(3):320-326(in Chinese).

殷鹏飞,龚会平,刘正清，等. 紫外-可见吸收、荧光光谱研究CdTe/CdS量子点与盐酸药根碱的相互作用及其应用[J]. 应用化学,2012,29(3):320-326.

[11] LI Pingping,YIN Pengfei,GONG Huiping,et al. A Study on the Interaction Between CdTe/CdS Quantum Dots with Mitomycin C and Its Analytical Application[J]. Chinese J Appl Chem,2012,29(3):320-326. (in Chinese).

李萍萍,殷鹏飞,龚会平,等. CdTe/CdS量子点与丝裂霉素的相互作用及其应用[J]. 应用化学,2012,29(6):705-710.

[12] Liu H,Tang J,Kramer IJ,et al. Electron Acceptor Materials Engineering in Colloidal Quantum Dot Solar Cells[J]. Adv Mater,2012,23:3832-3837.

[13] Scheibner M,Schmidt T,Worschech L,et al. Superradiance of Quantum Dots[J]. Nat Phys, 2007,3:106-110.

[14] Luo Q Y,Lin Y,Li Y,et al. Nanomechanical Analysis of Yeast Cells in CdSe Quantum Dot Biosynthesis[J]. Small,2013,doi:10.1002/smll.201301940.

[15] Katsnelson M I,Novoselov K S,Geim A K. Chiral Tunnelling and the Klein Paradox in Graphene[J]. Nat Phys,2006,2:620-625.

[16] Sanderson K. A Small Industry could be on the Verge of a Boom, Reports Katharine Sanderson[J]. Nature,2009,459:760-761.

[17] Dickerson M B,Sandhage K H,Naik R R. Protein- and Peptide-Directed Syntheses of Inorganic Materials[J]. Chem Rev,2008,108:4935-4978.

[18] Singh S C,Mishra S K,Srivastava R K,et al. Optical Properties of Selenium Quantum Dots Produced with Laser Irradiation of Water Suspended Se Nanoparticles[J]. J Phys Chem C,2010,114:17374-17384.

[19] Tikhomirov G,Hoogland S,Lee PE,et al. DNA-based Programming of Quantum Dot Valency, Self-assembly and Luminescence[J]. Nat Nano 2011,6:485-490.

[20] Kim T H,Cho K S,Lee E K,et al.Full-colour Quantum Dot DisplaysFabricated by Transfer Printing[J]. Nat Photon,5:176-182.

[21] Kamat PV,Quantum Dot Solar Cells. Semiconductor Nanocrystals as Light Harvesters[J]. J Phys Chem C,2008,112:18737-18753.

[22] Li F,Chen Y,Chen H,et al. Monofunctionalization of Protein Nanocages[J]. J Am Chem Soc,2011,133:20040-20043.

[23] Chan W C,Nie S. Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection[J]. Science,1998,281:2016-2018.

[24] Bruchez M,Moronne M,Gin P,et al. Semiconductor Nanocrystals as Fluorescent Biological Labels[J]. Science,1998,281:2013-2016.

[25] Liu J,Lau SK,Varma VA,et al. Multiplexed Detection and Characterization of Rare Tumor Cells in Hodgkin′s Lymphoma with Multicolor Quantum Dots[J]. Anal Chem,2010,82:6237-6243.

[26] Liu J,Lau S K,Varma V A,et al. Molecular Mapping of Tumor Heterogeneity on Clinical Tissue Specimens with Multiplexed Quantum Dots[J]. ACS Nano,2010,4:2755-2765.

[27] Liu SL,Li J,Zhang ZL,et al. Fast and High-Accuracy Localization for Three-Dimensional Single-Particle Tracking[J]. Sci Rep,2013,doi:10.1038/srep02462.

[28] Cassette E,Pons T,Bouet C,et al. Synthesisand Characterization of Near-Infrared CuInSe/ZnS Core/Shell Quantum Dots for In vivo Imaging[J]. Chem Mater,2011,22:6117-6124.

[29] Midgett AG,Hillhouse HW,Hughes BK,et al. Flowing versus Static Conditions for Measuring Multiple Exciton Generation in PbSe Quantum Dots[J]. J Phys Chem C,2010,114:17486-17500.

[30] Lord S J,Lee H l D,Moerner W E. Single-Molecule Spectroscopy and Imaging of Biomolecules in Living Cells[J]. Anal Chem,2010,82:2192-2203.

[31] Vannoy C H,Xu J,Leblanc R M. Bioimaging and Self-Assembly of Lysozyme Fibrils Utilizing CdSe/ZnS Quantum Dots[J]. J Phys Chem C,2009,114:766-773.

[32] Neo M S,Venkatram N,Li G S,et al. Synthesis of PbS/CdS Core-Shell QDs and Their Nonlinear Optical Properties[J]. J Phys Chem C,2010,114:18037-18044.

[33] Rehberg M,Praetner M,Leite CF,et al. Quantum Dots Modulate Leukocyte Adhesion and Transmigration Depending on Their Surface Modification[J]. Nano Lett,2010,10:3656-3664.

[34] Medintz I L,Uyeda H T,Goldman E R,et al. Quantum Qot Bioconjugates for Iimaging, Labelling and Sensing[J]. Nat Mater,2005,4:435-446.

[35] Allen P M,Bawendi M G. Ternary Ⅰ-Ⅲ-Ⅵ Quantum Dots Luminescent in the Red to Near-Infrared[J]. J Am Chem Soc,2008,130:9240-9241.

[36] Mandal A,Tamai N. Influence of Acid on Luminescence Properties of Thioglycolic Acid-Capped CdTe Quantum Dots[J]. J Phys Chem C,2008,112:8244-8250.

[37] Lee S,Xie J,Chen X. Peptides and Peptide Hormones for Molecular Imaging and Disease Diagnosis[J]. Chem Rev,2010,110:3087-3111.

[38] Murray C B,Norris D J,Bawendi M G. Synthesis and Characterization of Nearly Monodisperse CdE(E=sulfur, selenium, tellurium) Semiconductor Nanocrystallites[J]. J Am Chem Soc,1993,115:8706-8715.

[39] Hines M A,Guyot-Sionnest P. Synthesis and Characterization of Strongly Luminescing ZnS-Capped CdSe Nanocrystals[J]. J Phys Chem,1996,100:468-471.

[40] Peng Z A,Peng X. Formation of High-Quality CdTe, CdSe, and CdS Nanocrystals Using CdO as Precursor[J]. J Am Chem Soc,2000,123:183-184.

[41] Vossmeyer T,Katsikas L,Giersig M,et al. CdS Nanoclusters:Synthesis, Characterization, Size Dependent Oscillator Strength, Temperature Shift of the Excitonic Transition Energy, and Reversible Absorbance Shift[J]. J Phys Chem,1994,98:7665-7673.

[42] Akerman M E,Chan W C W,Laakkonen P,et al. Nanocrystal Targeting in vivo[J]. Proc Nat Acad Sci USA,2002,99:12617-12621.

[43] Mamedova N N,Kotov N A,Rogach A L,et al. Albumin-CdTe Nanoparticle Bioconjugates:Preparation, Structure, and Interunit Energy Transfer with Antenna Effect[J]. Nano Lett,2001,1:281-286.

[44] Putzer M A,Rogers J S,Bazan G C. Intramolecular Nucleophilic Substitution on Coordinated Borabenzenes:A New Entry into Boratabenzene Complexes[J]. J Am Chem Soc,1999,121:8112-8113.

[45] Dabbousi B O,Rodriguez-Viejo J,Mikulec F V,et al. (CdSe)ZnS Core-Shell Quantum Dots:Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites[J]. J Phys Chem B,1997,101:9463-9475.

[46] Kim S,Fisher B,Eisler H-Jr,et al. Type-II Quantum Dots:CdTe/CdSe(Core/Shell) and CdSe/ZnTe(Core/Shell) Heterostructures[J]. J Am Chem Soc,2003,125:11466-11467.

[47] Gao X,Yang L,Petros JA,et al. In vivo Molecular and Cellular Imaging with Quantum Dots[J]. Curr Opin Chem Biol,2005,16:63-72.

[48] Wilson R,Spiller D G,Prior I A,et al. A Simple Method for Preparing Spectrally Encoded Magnetic Beads for MultiplexedDetection[J]. ACS Nano,2007,1:487-493.

[49] Kumar R,Ding H,Hu R,et al. In vitro and In vivo Optical Imaging Using Water-Dispersible, Noncytotoxic, Luminescent, Silica-Coated Quantum Rods[J]. Chem Mater,2010,22:2261-2267.

[50] Green M,Howman E. Semiconductor Quantum Dots and Free Radical Induced DNA Nicking[J]. Chem Commun,2005,1:121-123.

[51] Cho SJ,Maysinger D,Jain M,et al. Long-Term Exposure to CdTe Quantum Dots Causes Functional Impairments in Live Cells[J]. Langmuir,2007,23:1974-1980.

[52] Mahto S K,Park C,Yoon T H,et al. Assessment of Cytocompatibility of Surface-modified CdSe/ZnSe Quantum Dots for BALB/3T3 Fibroblast Cells[J]. Toxico In Vitro,2010,24:1070-1077.

[53] Shan Y,Wang Z,Hao X,et al. Locating the Band III Protein in Quasi-native Cell Membranes[J]. Anal Meth 2010,2:805-808.

[54] Jiang J,Hao X,Cai M,et al. Localization of Na+-K+ ATPases in Quasi-native Cell Membranes[J]. Nano Lett,2009,9:4489-4493.

[55] Neuhauser R G,Shimizu K T,Woo W K,et al. Correlation Between Fluorescence Intermittency and Spectral Diffusion in Single Semiconductor Quantum Dots[J]. Phys Rev Lett,2000,85:3301-3304.

[56] Dubertret B,Skourides P,Norris D J,et al. In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles[J]. Science,2002,298:1759-1762.

[57] Rieger S,Kulkarni R P,Darcy D,et al. Quantum Dots are Powerful Multipurpose Vital Llabeling Agents in Zebrafish Embryos[J]. Developmental Dynamics,2005,234:670-681.

[58] Jaiswal J K,Mattoussi H,Mauro J M,et al. Long-term Multiple Color Imaging of Live Cells Using Quantum Dot Bioconjugates[J]. Nat Biotech,2003,21:47-51.

[59] Hanaki K-i,Momo A,Oku T,et al. Semiconductor Quantum Dot/Albumin Complex is a Long-life and Highly Photostable Endosome Marker[J]. Biochem Biophys Res Commun,2003,302:496-501.

[60] Mansson A,Sundberg M,Balaz M,et al. In Vitro Sliding of Actin Filaments Labelled with Single Quantum Dots[J]. Biochem Biophys Res Commun,2004,314:529-534.

[61] Kaul Z,Yaguchi T,Kaul S C,et al. Mortalin Imaging in Normal and Cancer Cells with Quantum Dot Immuno-conjugates[J]. Cell Res,2003,13:503-507.

[62] Sukhanova A,Devy Jrm,Venteo L,et al. Biocompatible Fluorescent Nanocrystals for Immunolabeling of Membrane Proteins and Cells[J]. Anal Biochem,2004,324:60-67.

[63] Nisman R,Dellaire G,Ren Y,et al. Application of Quantum Dots as Probesfor Correlative Fluorescence, Conventional, and Energy-filtered Transmission Electron Microscopy[J]. J Histochem Cytochem,2004,52:13-18.

[64] Rosenthal S J,Tomlinson I,Adkins E M,et al. Targeting Cell Surface Receptors with Ligand-Conjugated Nanocrystals[J]. J Am Chem Soc,2002,124:4586-4594.

[65] Dahan M,Lavi S,Luccardini C,et al. Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking[J]. Science,2003,302:442-445.

[66] Lidke DS,Nagy P,Heintzmann R,et al. Quantum Dot Ligands Provide New Insights into ErbB/HER Receptor-mediated Signal Transduction[J]. Nat Biotech,2004,22:198-203.

[67] Howarth M,Takao K,Hayashi Y,et al. Targeting Quantum Dots to Surface Proteins in Living Cells with Biotin Ligase[J]. Proc Nat Acad Sci USA,2005,102:7583-7588.

[68] Giepmans B N G,Deerinck T J,Smarr B L,et al. Correlated Llight and Electron Microscopic Imaging of Multiple Endogenous Proteins Using Quantum Dots[J]. Nat Meth,2005,2:743-749.

[69] Sundara Rajan S,Vu T Q. Quantum Dots Monitor TrkA Receptor Dynamics in the Interior of Neural PC12 Cells[J]. Nano Lett,2006,6:2049-2059.

[70] Hoshino A,Fujioka K,Oku T,et al. Quantum Dots Targeted to the Assigned Organelle in Living Cells[J]. Microbiol Immunol,2004,48:985-994.

[71] Santra S Y H,Stanley J T,Holloway P H,et al. Rapid and Effective Labeling of Brain Tissue using TAT-conjugated CdS:Mn/ZnS Quantum Dots[J]. Chem Commun,2005,25:3144-3146.

[72] Pellegrino T,Parak WJ,Boudreau R,et al. Quantum Dot-based Cell Motility Assay[J]. Differentiation,2003,71:542-548.

[73] Mattheakis L C,Dias J M,Choi Y J,et al. Optical Coding of Mammalian Cells using Semiconductor Quantum Dots[J]. Anal Biochem,2004,327:200-208.

[74] Ramachandran S,Merrill N E,Blick R H,et al. Colloidal Quantum Dots Initiating Current Bursts in Lipid Bilayers[J]. Biosens Bioelectron,2005,20:2173-2176.

[75] Kloepfer J A,Mielke R E,Wong M S,et al. Quantum Dots as Strain- and Metabolism-Specific Microbiological Labels[J]. Appl Environ Microbiol,2003,69:4205-4213.

[76] Marshall D,Pedley R B,Boden J A,et al. Polyethylene Glycol Modification of a Galactosylated Streptavidin Clearing Agent:Effects on Immunogenicity and Clearance of a Biotinylated Anti-tumour Antibody[J]. Br J Cancer,1996,73:565-572.

[77] Cai W,Shin D W,Chen K,et al. Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects[J]. Nano Lett,2006,6:669-676.

[78] Lim YT,Kim S,Nakayama A,et al. Selection of Quantum Dot Wavelengths for Biomedical Assays and Iimaging[J]. Mol Imaging,2003,2:50-64.

[79] Frangioni J V. In Vivo Near-infrared Fluorescence Imaging[J]. Curr Opin Chem Biol,2003,7:626-634.

[80] So M K,Xu C,Loening A M,et al. Self-illuminating Quantum Dot Conjugates for in Vivo Imaging[J]. Nat Biotech,2006,24:339-343.

[81] Brannon-Peppas L,Blanchette J O. Nanoparticle and Targeted Systems for Cancer Ttherapy[J]. Adv Drug Deliver Rev,2004,56:1649-1659.

[82] Peracchia M T,Fattal E,Besnard M,et al. Stealth PEGylated Polycyanoacrylate Nanoparticles for Intravenous Administration and Splenic Targeting[J]. J Control Release,1999,60:121-128.

[83] Porkka K,Laakkonen P,Hoffman JA,et al. A Fragment of the HMGN2 Protein Homes to the Nuclei of Tumor Cells and Tumor Endothelial Cells In Vivo[J]. Proc Nat Acad Sci USA,2002,99:7444-7449.

[84] Morgan NY,English S,Chen W,et al. Real Time In Vvivo Non-invasive Optical Iimaging using Near-infrared Fluorescent Quantum Dots[J]. Acad Radiol,2005,12:313-323.

[85] Chen L,Zurita AJ,Ardelt PU,et al. Design and Validation of a Bifunctional Ligand Display System for Receptor Targeting[J]. Chem Biol,2004,11:1081-1091.

[86] Ballou B,Lagerholm BC,Ernst LA,et al. Noninvasive Imaging of Quantum Dots in Mice[J]. Biocon Chem,2003,15:79-86.

[87] Gao X,Cui Y,Levenson RM,et al. In Vivo Cancer Targeting and Iimaging with Semiconductor Quantum Dots[J]. Nat Biotech,2004,22:969-976.

[88] Chang S S,Reuter V E,Heston WDW,et al. Metastatic Renal Cell Carcinoma Neovasculature Expresses Prostate-specific Membrane Antigen[J]. Urology,2001,57:801-805.

[89] Hoffman R M. Green Fluorescent Protein Imaging of Tumour Growth, Metastasis, and Angiogenesis in Mouse Models[J]. Lancet Oncol,2002,3:546-556.

[90] Yang M,Baranov E,Wang JW,et al. Direct External Imaging of Nascent Cancer, Tumor Progression, Angiogenesis, and Metastasis on Internal Organs in the Fluorescent Orthotopic Model[J]. Proc Nat Acad Sci USA,2002,99:3824-3829.

[91] Akerman M E,Chan W C W,Laakkonen P,et al. Nanocrystal Targeting in Vivo[J]. Proc Nat Acad Sci USA,2002,99:12617-12621.

[92] Jamieson T,Bakhshi R,Petrova D,et al. Biological Applications of Quantum Dots[J]. Biomaterials,2007,28:4717-4732.

[93] Larson D R,Zipfel W R,Williams RM,et al. Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo[J]. Science,2003,300:1434-1436.

[94] Jakub JW,Pendas S,Reintgen DS. Current Status of Sentinel Lymph Node Mapping and Biopsy:Facts and Controversies[J]. The Oncologist,2003,8:59-68.

[95] Parungo C P,Colson Y L,Kim S W,et al. SEntinel Lymph Node Mapping of the Pleural Space[J]. Chest J,2005,127:1799-1804.

[96] Cimmino V M,Brown A C,Szocik J F,et al. Allergic Reactions to Isosulfan Blue during Sentinel Node biopsy Common Event[J]. Surgery,2001,130:439-442.

[97] Soltesz E G,Kim S,Laurence R G,et al. Intraoperative Sentinel Lymph Node Mapping of the Lung Using Near-Infrared Fluorescent Quantum Dots[J]. Ann Thorac Surg,2005,79:269-277.

[98] Kim S H,Suh H J,Koh K N,et al. Surface Plasmon Resonance Study on the Interaction of Photochromic Spironaphthoxazine with L-phenylalanine in Self-assembled Monolayers on Gold[J]. Dyes Pigm,2004,62:93-97.

[99] Parungo C P,Ohnishi S,Kim S W,et al. Intraoperative Identification of Esophageal Sentinel Lymph Nodes with Near-infrared Fluorescence Imaging[J]. J Thorac Cardiov Sur,2005,129:844-850.

[100] Tanaka E,Choi H,Fujii H,et al. Image-Guided Oncologic Surgery Using Invisible Light:Completed Pre-Clinical Development for Sentinel Lymph Node Mapping[J]. Ann Surg Oncol,2006,13:1671-1681.

[101] Lee LY,Ong SL,Hu JY,et al. Use of Semiconductor Quantum Dots for Photostable Immunofluorescence Labeling of Cryptosporidium Parvum[J]. Appl Environ Microbiol,2004,70:5732-5736.

[102] Zhu L,Ang S,Liu W T. Quantum Dots as a Novel Immunofluorescent Detection System for Cryptosporidium parvum and Giardia lamblia[J]. Appl Environ Microbiol,2004,70:597-598.

[103] Yang L,Li Y. Simultaneous Detection of Escherichia Coli O157[ratio]H7 and Salmonella Typhimurium Using Quantum Dots as Fluorescence Llabels[J]. Analyst,2006,131:394-401.

[104] Tully E,Hearty S,Leonard P,et al. The Development of Rapid Fluorescence-based Immunoassays, Using Quantum Dot-labelled Antibodies for the Detection of Listeria Monocytogenes Cellsurface Proteins[J]. Int J Biol Macromol,2006,39:127-134.

[105] Modun B,Morrissey J,Williams P. The Staphylococcal Transferrin Receptor:a Glycolytic Enzyme with Novel Functions[J]. Trend Microbiol,2000,8:231-237.

[106] Gerion D,Chen F,Kannan B,et al. Room-Temperature Single-Nucleotide Polymorphism and Multiallele DNA Detection Using Fluorescent Nanocrystals and Microarrays[J]. Anal Chem,2003,75:4766-4772.

[107] Agrawal A,Tripp R A,Anderson L J,et al. Real-Time Detection of Virus Particles and Viral Protein Expression with Two-Color Nanoparticle Probes[J]. J Virology,2005,79:8625-8628.

[108] Goldman E R,Anderson G P,Tran P T,et al. Conjugation of Luminescent Quantum Dots with Antibodies Using an Engineered Adaptor Protein To Provide New Reagents for Fluoroimmunoassays[J]. Anal Chem,2002,74:841-847.

[109] Goldman E R,Balighian E D,Mattoussi H,et al. Avidin:A Natural Bridge for Quantum Dot-Antibody Conjugates[J]. J Am Chem Soc,2002,124:6378-6382.

[110] Goldman E R,Clapp AR,Anderson GP,et al. Multiplexed Toxin Analysis Using Four Colors of Quantum Dot Fluororeagents[J]. Anal Chem,2003,76:684-688.

[111] Park H Y,Kim K,Hong S,et al. Compact and Versatile Nickel-Nitrilotriacetate-Modified Quantum Dots for Protein Imaging and Fo^rster Resonance Energy Transfer Based Assay[J]. Langmuir,2009,26:7327-7333.

[112] Derfus A M,Chan W C W,Bhatia S N. Probing the Cytotoxicity of Semiconductor Quantum Dots[J]. Nano Lett,2003,4:11-18.

[113] Tan S J,Jana N R,Gao S,et al. Surface-Ligand-Dependent Cellular Interaction, Subcellular Localization, and Cytotoxicity of Polymer-Coated Quantum Dots[J]. Chem Mater,2010,22:2239-2247.

[114] Qu Y,Li W,Zhou Y,et al. Full Assessment of Fate and Physiological Behavior of Quantum Dots Utilizing Caenorhabditis elegans as a Model Organism[J]. Nano Lett,2011,11:3174-3183.

[115] Navarro D A G,Watson D F,Aga D S,et al. Natural Organic Matter-Mediated Phase Transfer of Quantum Dots in the Aquatic Environment[J]. Environ Sci Technol,2009,43:677-682.

[116] Maity A R,Jana N R, Chitosan-Cholesterol-Based Cellular Delivery of Anionic Nanoparticles[J]. J Phys Chem C,2010,115:137-144.

[117] Kirchner C,Liedl T,Kudera S,et al. Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles[J]. Nano Lett,2004,5:331-338.

[118] Su Y,Hu M,Fan C,et al. The Cytotoxicity of CdTe Quantum Dots and the Relative Contributions from Released Cadmium Iions and Nanoparticle Properties[J]. Biomaterials,2010,31:4829-4834.

[119] Chang E,Yu W W,Colvin V L,et al. Quantifying the Influence of Surface Coatings on Quantum Dot Uptake in Cells[J]. J Biomed Nanotech,2005,1:397-401.

[120] Clark R J,Dang M K M,Veinot J G C. Exploration of Organic Acid Chain Length on Water-Soluble Silicon Quantum Dot Surfaces[J]. Langmuir,2010,26:15657-15664.

[121] Li Y,Zhou Y,Wang H Y,et al. Chirality of Glutathione Surface Coating Affects the Cytotoxicity of Quantum Dots[J]. Angew Chem Int Ed Engl,2011,50:5860-5864.

Application of Quantum Dots in Biological Detection

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[6]	ZHANG Ping-Ping, YANG Gao-Ling, KANG Guo-Guo, SHI Jian-Bing, ZHONG Hai-Zheng. Photolithography of Colloidal Quantum Dots for Display Applications [J]. Chinese Journal of Applied Chemistry, 2021, 38(9): 1175-1188.
[7]	BO Chun-Hui, JIANG Wei-Jia, WANG Yu-Gao, SHI Li-Hong, DONG Chuan. Research Progress on Synthesis of Coal-based Carbon Quantum Dots [J]. Chinese Journal of Applied Chemistry, 2021, 38(7): 767-788.
[8]	WEN Guang-Ming, JIAO Ting, DU Xiao-Yan, LI Zhong-Ping. Preparation and Application of Sulfur and Nitrogen Co-doped Carbon Quantum Dots [J]. Chinese Journal of Applied Chemistry, 2021, 38(6): 722-730.
[9]	HAO Li-Juan, WANG Ting, DONG Guo-Hua, ZHANG Wen-Zhi, BAI Li-Ming, DU Hai-Yao, LANG Kun, LI Xin. Preparation of Green Carbon Quantum Dots from Corn Starch and Hydrogen Ion/Hydroxyl Ion Regulated Fluorescent Switch Performance [J]. Chinese Journal of Applied Chemistry, 2021, 38(2): 202-211.
[10]	ZHU Meng-Meng, BAI Jue-Yao, CHEN Ren-Jie, LI Hui-Li. Synthesis and Properties of B-Site Doped All-Inorganic Perovskite Quantum Dots [J]. Chinese Journal of Applied Chemistry, 2021, 38(12): 1541-1555.
[11]	ZHOU Chao, SHENG Cheng-Ju, WEN Lin-Lin. Preparation of Imidazolium Salt-based Poly(ionic liquids) Antibacterial Agent and Its Application in Hydrogel Dressing [J]. Chinese Journal of Applied Chemistry, 2021, 38(1): 51-59.
[12]	HUANG Jieying, LIU Jianjun, ZUO Shengli, HAN Wenjing, YU Yingchun. Preparation of Ag₃PO₄ Quantum Dots/g-C₃N₄ Nanosheet Composite Photocatalysts and Its Activity for Selective Oxidation of Benzyl Alcohol [J]. Chinese Journal of Applied Chemistry, 2020, 37(9): 1030-1037.
[13]	HUANG Guobin, LUO Dengfeng, ZHANG Maosheng. Preparation of CsPbX₃(X=Cl,Br,I) Perovskite Quantum Dots with Multicolor and High Luminescence Efficiency and Its Application in Light Emitting Diode Devices [J]. Chinese Journal of Applied Chemistry, 2019, 36(8): 932-938.
[14]	HUANG Guobin, LUO Dengfeng, ZHANG Maosheng. Preparation of CsPbX₃(X=Cl,Br,I) Perovskite Quantum Dots with Multicolor and High Luminescence Efficiency and Its Application in Light Emitting Diode Devices [J]. Chinese Journal of Applied Chemistry, 2019, 36(8): 0-.
[15]	ZHANG Yajing,JI Peng,HAN Deming,ZHAO Lihui,XU Yajuan,LIU Wenshu. Preparation of Graphene Nano Drug-Loading System and Its Killing Effect on Human Oral Squamous Cell Carcinoma Cells [J]. Chinese Journal of Applied Chemistry, 2019, 36(5): 564-570.