Chinese Journal of Applied Chemistry ›› 2009, Vol. 26 ›› Issue (10): 1206-1210.

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The study on the One-pot synthesis of Novel Pyrazol-3,4-Dihydropyrimidine

 LIU Jin-Gui, WANG Guo-Hui, DANG Shan   

  1. (College of Chemistry and Environmental Science,Henan Normal University,Xinxiang 453007)
  • Received:2008-10-15 Revised:2009-01-07 Published:2009-10-10 Online:2009-10-10

Abstract:

The Pyrazol-3,4-Dihydropyrimidines were synthesized by one-pot Biginelli cyclocondensation of Substituted-4-formylpyrazole,Ethyl acetoacetate,and Urea or Thiourea (1:3:3)in Ethanol, under the traditional heating or microwave irradiation conditions, while Ferric chloride was used as a catalyst. The structure of all products was characterized by elemental analysis,IR, 1H-NMR and 13C-NMR.

Key words: ferric chloride,Biginelli condensation,dihydropyrimidine,onepot synthesis,microwave irradiation

CLC Number: