Applications of Ugi Reaction to the Synthesis of Natural Products

doi:10.3724/SP.J.1095.2013.30002

Chinese Journal of Applied Chemistry

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Applications of Ugi Reaction to the Synthesis of Natural Products

ZHANG Feng¹, FANG Zheng¹, LI Xiaolin¹, HE Wei¹, YUAN Aibang², GUO Kai^2*

(1.College of Pharmaceutical Sciences;2.College of Biotechnology and
Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 211816,China)

Received:2013-01-04 Revised:2013-04-19 Published:2013-11-10 Online:2013-11-10
Contact: guo

Abstract

Abstract: Ugi reaction is an important multicomponent reaction to yield polycondensation α-amido amide in which a molecule of aldehyde or ketone, an amine, an isocyanide and a carboxylic acid were involved. The reaction not only possesses the advantages of mild reaction condition, high yield and atom economy, but also can couple with some classical chemical reactions, for example, Suzuki, Heck and Smiles. Therefore it has attracted more and more research interest in the synthesis of natural products. The article generally summarizes the application of Ugi reaction in the synthesis of natural products in recent decades.

Key words: Ugi reaction, natural products, synthesis

CLC Number:

O621.3

ZHANG Feng1, FANG Zheng1, LI Xiaolin1, HE Wei1, YUAN Aibang2, GUO Kai2*. Applications of Ugi Reaction to the Synthesis of Natural Products[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.30002.

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Applications of Ugi Reaction to the Synthesis of Natural Products

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