Chinese Journal of Applied Chemistry

Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (6): 0-.

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pH Reversibly Activated Asymmetric Cyanine Photosensitizer for Photodynamic Antibacterial

ZHAO Kaichaoa,ZHAO Xubcd*(),YAN Xiupingbcd*()   

  1. aSchool of Chemical and Material Engineering,Wuxi,Jiangsu 214122,China
    bInstitute of Analytical Food Safety, School of Food Science and Technology,Wuxi,Jiangsu 214122,China
    cState Key Laboratory of Food Science and Technology,Wuxi,Jiangsu 214122,China
    dInternational Joint Laboratory on Food Safety,Jiangnan University,Wuxi,Jiangsu 214122,China
  • Received:2020-03-27 Published:2020-06-01 Online:2020-07-09
  • Contact: ZHAO Xu,YAN Xiuping
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21804056), the Natural Science Foundation of Jiangsu Province, China(No.BK20180581), China Postdoctoral Science Foundation(No.2018M630511), and the Fundamental Research Funds for the Central Universities(No.JUSRP11846, No.JUSRP51714B)

Abstract:

The photodynamic bactericidal performance of a reversibly activated asymmetric cyanine (Acy) was studied. The results show that Acy can be specifically activated to produce singlet oxygen in the weakly acidic microenvironment of bacteria under the irradiation of 808 nm laser, and shows excellent photodynamic bactericidal effect on both E.coli and S.aureus, but has no photodynamic antibacterial effect under normal physiological condition. The specifically activated photodynamic feature of Acy effectively overcomes the shortcoming of non-specific damage to normal tissues in previous “always on” photosensitizers, making Acy promising for specific antibacteria.

Key words: pH reversible activation, photodynamic antibacteria, near infrared, asymmetric cyanine

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