Microwave-assisted Synthesis of Benzothiazole Derivatives in Aqueous Solution

doi:10.3724/SP.J.1095.2014.30357

Chinese Journal of Applied Chemistry

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Microwave-assisted Synthesis of Benzothiazole Derivatives in Aqueous Solution

KE Fang^1*, WU Wen², LI Peng¹, LIN Chen¹

(1.Department of Pharmacy,Fujian Medical University,Fuzhou 350004,China;
2.Xiamen Maternity and Child care Hospital,Xiamen 361003,China)

Received:2013-07-17 Revised:2013-09-01 Published:2014-06-10 Online:2014-06-10
About author:
Supported by Natural Science Foundation of China(81202560); Fujian Provincial Foundation (2012J05150). Corresponding gauthor: Tel/Fax:0591-22862016; E-mail:kefang612@163.com; Research interests: pharmaceutical chemistry, catalytic chemistry

Abstract

Abstract: A novel protocol, efficient, inexpensive for the microwave-assisted copper-catalyzed synthesis of benzothiazoles derivatives through the reaction of 2-iodoanilines with aldehydes and KSCN in aqueous solution was investigated. The reactions was catalyzed by a combination of CuI and 1,10-phenanthroline with Cs2CO3 as a base and in neat water at 100 ℃ for 30 min. A variety of benzothiazoles can be synthesized in an excellent yield up to 94%.

Key words: microwave-assisted synthesis, iodoaniline, aldehyde, benzothiazoles

CLC Number:

O621.3

KE Fang1*, WU Wen2, LI Peng1, LIN Chen1. Microwave-assisted Synthesis of Benzothiazole Derivatives in Aqueous Solution[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30357.

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Microwave-assisted Synthesis of Benzothiazole Derivatives in Aqueous Solution

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