Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (2): 182-187.DOI: 10.11944/j.issn.1000-0518.2019.02.180094

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Copper-catalyzed Microwave-Assisted Synthesis of N,N-Dimethyl-2-benzoxazolamine Derivatives

LIN Chena,LIN Xiaoyana,ZHANG Penga,XU Yiwena,XU Jianhuaab,KE Fangab*()   

  1. aDepartment of Pharmacy,Fujian Medical University,Fuzhou 350004,China
    bInstitute of Materia Medica,Fujian Medical University,Fuzhou 350004,China
  • Received:2018-03-30 Online:2019-02-01 Published:2019-01-31
  • Contact: KE Fang
  • Supported by:
    Supported by the Department of Fujian Province Natural Science and Technology Foundation(No.2016J01686, No.2016J01372, No.2016Y9051, No.2017J01820), the Fund of Fujian Medical University(No.2015MP008)


Microwave-assisted one-pot synthesis of a variety of N,N-dimethyl-2-benzoxazolamine derivatives were achieved by the cascade reaction of substituted 2-iodoanilines with dimethylcarbamothioic chloride in pyridine in the presence of CuI at 100 ℃ with moderate to good yields(up to 90%).

Key words: microwave-assisted synthesis, N,N-dimethyl-2-benzoxazolamines, 2-iodoanilines