Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (01): 121-122.DOI: 10.3724/SP.J.1095.2010.00234

• Communications • Previous Articles    

Asymmetric Addition of Phenylacetylene and Benzaldehyde Catalyzed by Chiral 1,1'-Bi-2-naphthol Derivatives

WANG Qin1*, ZHANG Yanjun2, DU Xi2, PENG Ruiguang1   

  1. (1.Department of Pharmacy;2.Staff Room of Chemistry,Luzhou Medical College,Luzhou 646000)
  • Received:2010-04-21 Revised:2010-06-02 Published:2011-01-10 Online:2011-01-10
  • Contact: WANG Qin

Abstract:

Chiral 3,3′-substituted 1,1′-bi-2-napthol(BINOL) derivatives were synthesized from BINOL. The asymmetric addition of phenylacetylene and benzaldehyde in the presence of the BINOL derivative and diethyl zinc afforded the corresponding propargylic alcohols with 73% yield and 40% enatiomeric excess.

Key words: substitued bi-naphthol, asymmetric addition, propargylic alcohol

CLC Number: