Abstract: A new fluorous proline-derived ligand has been synthesized and applied to the copper-catalyzed Henry reaction. The reaction conditions were optimized in terms of ligand, Cu source, solvent and base taking the reaction of 4-nitrobenzaldehyde and nitromethane as a model reaction. The optimized conditions are:using fluorous proline imide as ligand, copper acetate as copper source, methanol as solvent and triethylamine as base and the reaction was carried out at room temperature. A wide range of substrates were investigated under the optimized conditions and the yields of the target products varied from 53% to 98%.

Key words: &, beta, -niroalcohols, Henry reaction, fluorous proline ligand, copper catalyst