Chinese Journal of Applied Chemistry

• Communications • Previous Articles    

Enantioselective Synthesis of Chiral 2-Phenylpropanol via Rh-catalyzed Asymmetric Hydrogenation of 2-Phenylprop-2-en-1-ol

DUAN Zhengchao1*, WANG Lianzhi1, QU Taoli1, ZUO Xiaoyu1, HU Xiangping2*, ZHENG Zhuo2   

  1. (1.School of Chemical and Environmental Engineering,
    Hubei University for Nationalities,Enshi 445000,China;
    2.Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China)
  • Received:2014-02-25 Revised:2014-05-07 Published:2014-10-09 Online:2014-10-09
  • Contact: Duan Zheng-chao

Abstract: Rhodium-catalyzed asymmetric hydrogenation of 2-phenylprop-2-en-1-ol was investigated for the first time. Enantioselective synthesis of chiral 2-phenylpropanol with up to 70% ee was achieved through screen on a series of monodentate ligands and bidentate ligands.

Key words: chiral phenylpropanol, Rh(Ⅰ) complex, asymmetric catalytic hydrogenation, phenylprop-en-ol, chiral phosphorus ligand

CLC Number: