Abstract: Acridinedione derivatives were synthesized by refluxing aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione and aniline/4-methyl-aniline in aqueous solutions via a multi-component one-pot condensation process. The yields of the target compounds varied from 69% to 90%. The established protocol possesses the virtues of environmental benign and high efficiency toward the preparation of acridinedione derivatives.

Key words: aldehyde, dimedone, acridinedione, three-component condensation, water