Research Progress of Multicolor Colorimetric Method in Biosensing Platform

doi:10.19894/j.issn.1000-0518.230085

Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (1): 3-20.DOI: 10.19894/j.issn.1000-0518.230085

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Research Progress of Multicolor Colorimetric Method in Biosensing Platform

Yi XU, Meng-Yao LIN, Xiao-Qun GONG()

School of Life Science，Tianjin University，Tianjin 300072，China

Received:2023-04-03 Accepted:2023-08-03 Published:2024-01-01 Online:2024-01-30
Contact: Xiao-Qun GONG
About author:gongxiaoqun@tju.edu.cn
Supported by:
the Scientific and Technical Supporting Key Project of Tianjin, China(20YFZCSY00990)

Abstract

Abstract:

The colorimetric method is a common detection method in biosensing， which has received much attention because of its high sensitivity and specificity. Among them， multicolor colorimetric method based on multicolor probes has become a hot research topic in recent years. Its sensitivity is significantly higher than that of monochromatic colorimetric method， and it has higher resolution which can be visualized for semi-quantitative detection by naked eye recognition， quickly quantified by calculating color ratios or based on smartphone image processing software. Based on three different color development mechanisms： organic small molecule fluorescence， nanomaterial color development and enzymatic reaction color development， the detection mechanisms of multicolor fluorescent small molecule probes， multicolor nanomaterial colorimetric probes and multicolor enzymatic reaction colorimetric probes are reviewed and their applications in practical sample detection are discussed. The challenges and future development opportunities are also discussed.

Key words: Fluorescent molecular probes, Gold nanoparticles, Silver nanoparticles, Quantum dots, Enzyme-linked immunosorbent assay, Nanoenzymes

CLC Number:

O652.7

Yi XU, Meng-Yao LIN, Xiao-Qun GONG. Research Progress of Multicolor Colorimetric Method in Biosensing Platform[J]. Chinese Journal of Applied Chemistry, 2024, 41(1): 3-20.

Figures/Tables 10

Fig.1 Principles and applications of two-photon fluorescent probes

Fig.2 Applications of multi-response targeted fluorescent probes

Fig.3 Applications of multi-response fluorescent lifetime probes

Fig.4 Applications of aggregated chromogenic multicolor platforms

Fig.5 Applications of multi-rcolor colorimetric platform for surface growth etching

Fig.6 Applications of multicolor colorimetric platform based on the QDs

Fig.7 Applications of multicolor colorimetric platforms based on the UCNP and MOF

Fig.8 Applications of protease-catalyzed multicolor colorimetric platforms

Fig.9 Applications of a multi-color colorimetric platform based on DNA enzyme simulants

Fig.10 Applications of a nano-enzyme based multi-color colorimetric platform

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Research Progress of Multicolor Colorimetric Method in Biosensing Platform

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