中华医学超声杂志

应用化学 ›› 2009, Vol. 26 ›› Issue (6): 662-666.

• 研究论文 • 上一篇    下一篇

有机锡配合物{[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2的合成、结构和性质研究

张复兴,王剑秋,邝代治,,,许志锋   

  1. 衡阳师范学院
  • 收稿日期:2008-06-17 修回日期:2008-10-09 出版日期:2009-06-10 发布日期:2009-06-10
  • 通讯作者: 邝代治
  • 基金资助:
    湖南省自然科学基金(05JJ40015，06JJ50022)

Synthesis, Crystal Structure and Properties of Organotin Compound{[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2

  • Received:2008-06-17 Revised:2008-10-09 Published:2009-06-10 Online:2009-06-10

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摘要：

二(o-甲基苄基)二氯化锡与N-(o-甲基苄基)羟胺在碱性条件下反应，合成了有机锡配合物{[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2。经X-射线衍射方法测定了化合物的晶体结构。该化合物晶体属三斜晶系，空间群P-1，晶体学参数 a =1.0604(5) nm，b =1.3078(7) nm，c = 1.3742(47 nm，α=105.174(12)?，β = 90.229(7)?，γ=101.028(6)?，Z = 1，V =1.8025(15) nm3，Dc=1.522Mg•m-3，?(MoKa)= 1.423 mm-1，F(000)= 834，R1=0.0455，wR2=0.1017。化合物是三个以Sn2O2构成的平面四元环组成的梯状结构，锡原子均为五配位的畸变三角双锥构型。测定了配合物的体外抗癌活性,结果表明配合物对WiDr和MCF-7等癌细胞有一定的抑制能力。

关键词: 二(o-甲基苄基)二氯化锡, N-(o-甲基苄基)羟胺, 合成, 晶体结构, 抗癌活性, 二(o-甲基苄基)二氯化锡, N-(o-甲基苄基)羟胺, 合成, 晶体结构, 抗癌活性

Abstract:

The organotin compound {[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2 was synthesized by the reaction of di(o-methylbenzyl)tin dichloride with N-(o-methylbenzyl)hydroxylamine. It’s structure has been determined by X-ray single crystal diffraction. Crystallorgaphic for the compound: Triclinic, P-1, a =1.0604(5) nm，b =1.3078(7) nm，c = 1.3742(47 nm，α=105.174(12)?，β = 90.229(7)?，γ=101.028(6)?，Z = 1，V =1.8025(15) nm3，Dc=1.522Mg•m-3，?(MoKa)= 1.423 mm-1，F(000)= 834，R1=0.0455，wR2=0.1017. In the compound, the tin ions are five-coordinated and exhibit distorted trigonal bipyramidal geometries.The complrx has a ladder-like structure, which is composed by three Sn2O2 planes. The brief investigation shows that this tin compound is antitumour activity in vitro against WiDr and MCF-7 tumour cells.

Key words: di(o-methylbenzyl)tin dichloride, N-(o-methylbenzyl)hydroxylamine, synthesis, crystal structure, antitumour activity

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