应用化学

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Bronsted酸催化合成α-氨基膦酸酯

姚元勇1,2,吴兰艳1,舒华1,唐帮成1*,薛伟2*   

  1. (1.铜仁学院生物与化学工程系,梵净山特色动植物资源重点实验室 铜仁 554300;
    2.贵州大学精细化工研究中心 贵阳 550025)
  • 收稿日期:2014-02-25 修回日期:2014-06-16 出版日期:2014-11-08 发布日期:2014-11-08
  • 通讯作者: 薛伟,教授; Tel/Fax:0851-8092090; E-mail:wxue@gzu.edu.cn; 研究方向:新农药的创制
  • 基金资助:
    贵州省教育厅“125”重大科技专项([2012]018);黔教合KY字([2011]005);铜市科研([2014]40-3)

Synthesis of α-Aminophosphonates by Bronsted Acid Catalysis

YAO Yuanyong1,2, WU Lanyan1, SHU Hua1, TANG Bangcheng1*, XUE Wei2*   

  1. (1.Department of Biological and Chemical Engineering,Fanjing Mountain Key Laboratory of
    Special Animal and Plant Resource,Tongren University,Tongren 554300,China;
    2.Center for Research & Development of Fine Chemicals,Guizhou University,Guiyang 550025,China)
  • Received:2014-02-25 Revised:2014-06-16 Published:2014-11-08 Online:2014-11-08

摘要: 以芳香胺和肉桂醛为原料,合成的芳香族亚胺为亲电试剂,亚磷酸二乙酯或亚磷酸三乙酯为亲核试剂,在10%(摩尔分数)磷酸催化剂(Bronsted acid)的作用下,通过催化剂与亲电试剂、亲核试剂之间共同形成的双氢键或单氢键的作用,成功地合成了α-氨基膦酸酯类化合物,收率可达到79%~85%。

关键词: Bronsted酸, &, alpha, -氨基膦酸酯, 氢键作用, 催化, 磷氢化反应

Abstract: Electrophilic aromatic imines synthesized by the condensation of aromatic amines with cinnamyl aldehyde were allowed to react with diethyl phosphite or triethyl phosphite as nucleophile in the presence of 10% molar fraction of phosphoric acid(Bronsted acid). The α-aminophosphonate derivatives were obtained through binary or single hydrogen bonding interaction of catalyst with nucleophiles and electrophiles in up to 79%~85% yields.

Key words: Bronsted acid, &, alpha, -aminophosphonate, hydrogen bonding interaction, catalysis, hydrophosphonylation

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