环己基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性

doi:10.11944/j.issn.1000-0518.2015.10.150059

摘要/Abstract

摘要：

采用环己基(三甲基硅基亚甲基)二氯化锡和芳香酸(物质的量比1:2)在三乙胺存在下,合成了8种新的混合二烃基锡化合物环己基(三甲基硅基亚甲基)锡二芳香酸酯。通过IR、¹H NMR、¹³C NMR和元素分析等技术手段对它们的结构进行了表征;部分化合物的生物活性测定初步结果表明,它们对肺腺癌细胞(A549)有较好的体外抗癌活性,抑制率均在75%以上。

关键词: 二烃基锡, 合成, 结构, 抗癌活性

Abstract:

Eight cyclohexyl((trimethylsilyl)methyl)stannanediyl bisarylcarboxylates were synthesized by the reaction of cyclohexyl(trimethylsilylmethyl)tin dichloride with arylcarboxylic acids. These compounds were characterized by IR, ¹H NMR and ¹³C NMR spectra and elemental analysis. The preliminary bioassay tests of these compounds show good antitumour activities in vitro against tumour cells A549 and the inhibition rates are over 75%.

Key words: diorganotin, synthesis, structure, antitumour activity

林森,吴亚弟,邓瑞红,曹迁永. 环己基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性[J]. 应用化学, 2015, 32(10): 1114-1119.

LIN Sen,WU Yadi,DENG Ruihong,CAO Qianyong. Synthesis,Structure and Antitumour Activity of Cyclohexyl((trimethylsilyl)methyl)stannanediyl Bisarylcarboxylates[J]. Chinese Journal of Applied Chemistry, 2015, 32(10): 1114-1119.

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