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石墨烯修饰电极的制备及其对对乙酰氨基酚的伏安测定

马心英*,吴义芳,李霞   

  1. (菏泽学院化学与化工系 菏泽 274015)
  • 收稿日期:2011-08-10 修回日期:2011-10-06 出版日期:2012-07-10 发布日期:2012-07-10
  • 通讯作者: 马心英，副教授; Tel:0530-5973928; Fax:0530-5696765; E-mail:lzhaojie@sohu.com; 研究方向：电分析、化学修饰电极
  • 基金资助:
    山东省高等学校科技计划项目（J10LB64），山东省自然科学基金资助项目（2R2009BM003）

Preparation of Graphene-modified Electrode and Voltammetric Determination of Acetaminophen

MA Xinying* , WU Yifang, LI Xia   

  1. (Department of Chemistry and Chemical Engineering,Heze University,Heze 274015,China)
  • Received:2011-08-10 Revised:2011-10-06 Published:2012-07-10 Online:2012-07-10

PDF

1534

被引次数

30 | 5

摘要： 利用滴涂的方法制备了石墨烯修饰电极；石墨烯修饰电极对对乙酰氨基酚（ACOP）的电化学氧化具有明显的催化作用。 研究了ACOP在石墨烯修饰电极上的电化学行为，建立了测定ACOP的电化学分析新方法。 考察了磷酸盐缓冲溶液的pH值对ACOP电化学行为的影响。 结果表明，氧化还原峰电位随pH值升高发生负移；在pH=6.0磷酸盐缓冲溶液中，对乙酰氨基酚在修饰电极上呈现一对灵敏的氧化还原峰。 对乙酰氨基酚在石墨烯修饰电极上的氧化峰峰电流与其浓度在6.00×10-7~4.00×10-5 mol/L范围内呈良好的线性关系，相关系数为0.994 0；检出限为5.00×10-8 mol/L。 其回归方程为：ipa(A)=3.00c+1.21×10-5。 该修饰电极具有良好的灵敏度、选择性和稳定性，可用于对乙酰氨基酚药片分析。

关键词: 化学修饰电极, 石墨烯, 对乙酰氨基酚

Abstract: A glassy carbon electrode was modified with graphene by casting. The modified electrode showed an excellent electrocatalytical effect on the oxidation of acetaminophen(ACOP). The voltammetric behavior and electrochemical analysis method of ACOP were studied on the modified electrode. The effect of pH value on the response of ACOP was studied in phosphate buffer solution(PBS). The results showed that the redox peak potential of ACOP shifted negatively with increasing pH value, and a pair of well-defined redox waves were obtained in PBS of pH=6.0. The oxidation peak currents of ACOP increased linearly with the concentration, in the range of 6.00×10-7~4.00×10-5 mol/L, the linear regression equation was ipa(A)=3.00c+1.21×10-5, with correlation coefficient 0.9940. The detection limit(S/N=3) was 5.00×10-8 mol/L. The graphene modified electrode showed a good sensitivity, selectivity and stability. It was applied to the ACOP tablets analysis.

Key words: hemically modified electrode, graphene, acetaminophen

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