中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (09): 1032-1037.DOI: 10.3724/SP.J.1095.2010.90729

• 研究论文 • 上一篇    下一篇

2,6-二(2’-咪唑啉-2’-基)吡啶合铬(Ⅲ)的合成及其与DNA的相互作用

张金艳1,肖小明1*,蒋艳1,谭年元2*   

  1. (1.湖南师范大学化学化工学院 长沙 410081;2.湖南工程学院化学化工学院 湘潭)
  • 收稿日期:2009-11-06 修回日期:2010-01-22 出版日期:2010-09-10 发布日期:2010-09-10
  • 通讯作者: 肖小明，男，教授; E-mail:xmxiao@hunnu.edu.cn; 研究方向：配位化学及电化学
  • 基金资助:
    湖南省教育厅重点课题资助项目(08A045)

Synthesis of Chromium (Ⅲ) Complex of 2,6-Di(2’-imidazoline-2’-yl) Pyridine and Its Interaction with DNA

ZHANG Jin-Yan1, XIAO Xiao-Ming1*, JIANG Yan1, TAN Nian-Yuan2   

  1. (1.College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081;
    2.College of Chemistry and Chemical Engineering,Hunan Institute of Engineering,Xiangtan)
  • Received:2009-11-06 Revised:2010-01-22 Published:2010-09-10 Online:2010-09-10

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摘要：

在微波辐射和无催化剂条件下，由吡啶2,6-二甲酸与乙二胺反应合成了2,6-二(2′-咪唑啉-2′-基)吡啶(L)，采用常规加热法合成其配合物[CrL2][NO3]3。 用核磁共振、红外光谱、元素分析、热重分析和摩尔电导率测试技术对其进行表征分析。 通过紫外吸收光谱和黏度测试，分别考察了配体及配合物与DNA的键合常数及其作用方式。 结果表明，配体L以氢键和沟面作用方式与DAN键合，而配合物以氢键和静电作用模式与DNA键合。 密度泛函理论(DFT)计算结果较好的解释了L及[CrL2]3+与DNA的相互作用模式。

关键词: 二(咪唑啉基)吡啶, 铬配合物, DNA, 微波辐射, DFT

Abstract:

2,6-Di(2′-imidazoline-2′-yl)pyridine(L) was synthesized from pyridine 2,6-dicarboxylic acid and ethylenediamine under microwave irradiation without catalyst. Its chromium complex [CrL2][NO3]3 was synthesized by the conventional method. The complex was characterized by IR spectrometry, elemental analysis, 1H NMR, TG-DSC and molar conductivity. The bindings of these two compounds to DNA were investigated by UV spectrometry and viscosity measurement. It is believed that the ligand may bind to DNA by hydrogen bonding and grooveface binding and the complex bind to DNA by hydrogen bonding and external electrostatic binding. The calculation results from density functional theory(DFT) with hybrid functional B3LYP is good agreement with the experimental phenomena.

Key words: di(imidazolineyl)Pyridine, Chromium(Ⅲ) complex, Deoxyribonucleic Acid, Microwave Irradiation, DFT

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