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多孔β-磷酸三钙/壳聚糖/聚乙烯醇复合水凝胶的制备与性能

欧阳君君,周莉*   

  1. (深圳大学化学与化工学院 深圳 518060)
  • 收稿日期:2011-10-12 修回日期:2012-01-12 出版日期:2012-09-10 发布日期:2012-09-10
  • 通讯作者: 周莉，教授; Tel:0755-26557381; Fax:0755-26536141; E-mail:zhouli_2050@163.com; 研究方向：无机有机复合功能材料、精细化工
  • 作者简介:通讯联系人：周莉，教授；Tel：0755-26557381；Fax：0755-26536141;E-mail:zhouli＿2050@163.com;研究方向：无机-有机复合材料、精细化工。

Preparation and Properties of Porous β-Tricalcium Phosphate/Chitosan/Polyvinyl Alcohol Composite Hydrogel

OUYANG Junjun，ZHOU Li*   

  1. (School of Chemistry and Chemical Engineering,Shenzhen University,Shenzhen 518060,China)
  • Received:2011-10-12 Revised:2012-01-12 Published:2012-09-10 Online:2012-09-10

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摘要： 以NaCl为致孔剂,采用溶盐致孔法制备了多孔β-磷酸三钙/壳聚糖/聚乙烯醇（β-TCP/CS/PVA）复合水凝胶材料。 通过对比其含水率、溶胀比、拉伸强度、X射线衍射谱图、SEM和热重分析曲线，探讨了在相同环境下壳聚糖与β-磷酸三钙（β-TCP）的不同用量对聚乙烯醇(PVA)的结晶度以及对材料性能的影响。 此复合材料含水率为70%~76%。 当壳聚糖与β-TCP的质量比为2∶8时，复合材料的拉伸强度为0.56 MPa，断裂伸长率达到370%，其较好的力学性能，足以承受正常人眼压，可用作人工角膜周边支架材料。

关键词: 壳聚糖, 聚乙烯醇, &, beta, -磷酸三钙, 水凝胶, 人工角膜支架

Abstract: Porous β-tricalcium phosphate/chitosan/polyvinyl alcohol(β-TCP/CS/PVA) composite hydrogel was prepared successfully by the freezing-thawing method using NaCl as porogen. The effects of different mass ratio of CS to β-TCP on the crystallinity of PVA and the performance of target β-TCP/CS/PVA composite hydrogel has been studied. The products were characterized by means of XRD, SEM， TG-DTA and their water uptake, swelling ratio, and tensile strength were also determined and compared. The water uptake of the hydrogel composite was about 70%~76%(mass fraction). When the mass ratio of CS to β-TCP was 2∶8, it exhibited good mechanical properties: tensile strength of 0.56 MPa and elongation at breakage of 370% which can withstand normal human eye pressure. Therefore, the porous β-TCP/CS/PVA hydrogel composite is promising to be used as the skirt for artificial cornea.

Key words: Chitosan, polyvinyl alcohol, &, beta, -tricalcium phosphate (&, beta, -TCP), hydrogel, the skirt of artificial cornea

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