中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (03): 295-299.DOI: 10.3724/SP.J.1095.2010.90218

• 研究论文 • 上一篇    下一篇

新型有机多胺Co(Ⅱ)配合物的合成、晶体结构及抑菌性能

卞昌华1,2,许兴友1,2*,姚成2,尹德帅3,范莹莹1   

  1. (1.淮阴工学院生命科学与化学工程学院 淮阴 223000；
    2.南京工业大学理学院 南京 210009；3.江苏工业学院 常州)
  • 收稿日期:2009-03-31 修回日期:2009-07-03 出版日期:2010-03-10 发布日期:2010-03-10
  • 通讯作者: 许兴友,教授; E-mail:xuxy@hyit.edu.cn; 研究方向：生物无机化学
  • 基金资助:
    江苏重大自然科学基金资助项目（07KJA15011）

Synthesis,Crystal Structure and Antimicrobial Activity of a Co(Ⅱ) complex of Polyamine

BIAN Chang-Hua1,2, HU Xing-You1,2*, TAO Cheng2, YIN De-Shuai3, FAN Ying-Ying1   

  1. (1.College of Life Science and Chemical Engineering,Huaiyin institute of Technology,Huaiyin 223000;
    2.College of Science,Nanjing University of Technology,Nanjing 210009;
    3.Department of Chemistry,Jiangsu Polytechnic University,Changzhou)
  • Received:2009-03-31 Revised:2009-07-03 Published:2010-03-10 Online:2010-03-10

PDF

867

摘要：

以1-氨乙基哌嗪和丙烯腈为原料合成了新型有机多胺1-（N,N-二氨基丙基）氨基乙基-4-氨基丙基哌嗪，并以此为配体，与高氯酸钴进行配位反应，得到其配合物[Co(L)HCl](ClO4)2的晶体。通过元素分析、测摩尔电导率和X射线衍射对所得晶体进行了分析。结果显示,该晶体结构属于四方晶系，空间群I4/m，a = 2.5006(3)，b = 2.5006(3) c = 0.85615(11) nm, Mr =594.79，V = 5.3534(10) nm3,Z=8, F(000)= 2488, Dc = 1.476g/cm3,μ(MoKα)= 0.989mm-1，最终偏离因子R1 = 0.0666, wR2 = 0.1852 ( I > 2σ( I) )。采用琼脂扩散法测定目标产物的抑菌性能。结果表明， [Co(L)HCl](ClO4)2对金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌、鳗弧菌均有一定的抑制作用。

关键词: 多胺, 配合物, 晶体, 抑菌性

Abstract:

A new organic polyamines 1-( N,N-2-aminopropyl) aminoethyl-4-aminopropyl piperazine was synthesized from 1-(2-aminoethyl)piperazine and Acrylonitrile. Based on this polyamines ligand and cobalt perchlorate，[Co(L)HCl](ClO4)2 was synthesized， and purple needle single crystal of this complex. The crystal was characterized by elemental analysis, Molar conductivity and determined by X-ray single crystal diffraction. X-ray data reveals that the titled complex crystallize in the orthorhombic system, space group I4/m, with a = 2.5006(3), b = 2.5006(3), c = 0.85615(11) nm, Mr =594.79，V= 5.3534(10) nm3, Z=8, F(000)= 2488, Dc = 1.476g/cm3, μ(MoKα)= 0.989mm-1，R1 = 0.0666, wR2 = 0.1852 ( I > 2σ( I) ). The complex was tested on antimicrobial activity with agar diffusion antimicrobial test and showed a certain anti-bacteriostatic property to staphylococcus aureus，escherichia coli，bacillus subtilis and Marine Vibrio.

Key words: polyamines, complex, crystal structure, antimicrobial

中图分类号: 

网站版权 © 应用化学     本网站备案：吉ICP备12000082号