耗散型石英晶体微天平在生物医用高分子材料中的应用

doi:10.11944/j.issn.1000-0518.2020.10.200078

摘要/Abstract

摘要： 石英晶体微天平(QCM)是一种基于石英晶体压电效应的分析检测技术,可实时在线提供石英晶体表面吸附层质量、厚度、粘弹性等信息,由此获得表面分子相互作用关系。耗散型石英晶体微天平(QCM-D)因其独特的对粘弹性的解析,使其在高分子材料中的应用迅速发展,尤其是生物医用高分子材料领域,已用来评价生物医用高分子材料的表界面相互作用,力学和生物相容性等。本文简单介绍了耗散型石英晶体微天平的基本原理及理论模型,重点综述了近几年QCM-D在高分子链构象、蛋白质吸附、生物大分子相互作用、药物释放以及水凝胶中的应用,并且展望了QCM-D的未来发展趋势。

关键词: 耗散型石英晶体微天平, 生物医用高分子材料, 粘弹性

Abstract: Quartz crystal microbalance (QCM) is an analytical technique based on the piezoelectric effect of quartz crystal, which can provide the information on the mass, thickness and viscoelasticity of the adsorbed layer on the surface of quartz crystal in real time, and thus obtain the surface molecular interaction relationship. Because of the unique viscoelastic analysis, QCM with dissipation (QCM-D) has been rapidly applied in the field of polymer material, especially for biomedical polymer materials. It has been used to evaluate the surface and interface interaction, mechanical property, and biocompatibility of biomedical biomaterials. In this review, the basic principle and theoretical model of QCM-D are briefly introduced. The application of QCM-D in the conformation of polymer chain, protein adsorption, biomolecular interactions, drug release and hydrogels in recent years are emphatically reviewed, and finally the future development trends of QCM-D is forecasted.

Key words: quartz crystal microbalance with dissipation, biomedical polymer materials, viscoelasticity

孙彬, 吕建华, 金晶, 赵桂艳. 耗散型石英晶体微天平在生物医用高分子材料中的应用[J]. 应用化学, 2020, 37(10): 1127-1136.

SUN Bin, LÜ Jianhua, JIN Jing, ZHAO Guiyan. Application of Quartz Crystal Microbalance with Dissipation in Biomedical Polymer Materials[J]. Chinese Journal of Applied Chemistry, 2020, 37(10): 1127-1136.

参考文献

[1] Konash P L,Bastiaans G J. Piezoelectric Crystals as Detectors in Liquid Chromatography[J]. Anal Chem,1980,52(12):1929-1931.
[2] Du Y Q,Jin J,Jiang W. A Study of Polyethylene Glycol Backfilling for Enhancing Target Recognition Using QCM-D and DPI[J]. J Mater Chem B,2018,6(39):6217-6224.
[3] DU Binyang,FAN Xiao,CAO Zeng,et al. Applications and Outlooks of Quartz Crystal Microbalance in Studies of Polymer Thin Flims[J]. Chinese J Anal Chem,2010,5(38):752-759(in Chinese).
杜滨阳,范潇,曹峥,等. 石英晶体微天平在聚合物薄膜研究中的应用与展望[J]. 分析化学,2010,5(38):151-158.
[4] Escobar Teran F,Arnau A,Garcia J V,et al. Gravimetric and Dynamic Deconvolution of Global EQCM Response of Carbon Nanotube Based Electrodes by AC-Electrogravimetry[J]. Electrochem Commun,2016,70:73-77.
[5] Hu Y,Jin J,Lang H,et al. pH Dependence of Adsorbed Fibrinogen Conformation and Its Effect on Platelet Adhesion[J]. Langmuir,2016,32(16):4086-4094.
[6] Olsson A L J,Wargenau A,Tufenkji N. Optimizing Bacteriophage Surface Densities for Bacterial Capture and Sensing in Quartz Crystal Microbalance with Dissipation Monitoring[J]. ACS Appl Mater Interfaces,2016,8(22):13698-13706.
[7] Lv J H,Jin J,Chen J Y,et al. Antifouling and Antibacterial Properties Constructed by Quaternary Ammonium and Benzyl Ester Derived from Lysine Methacrylamide[J]. ACS Appl Mater Interfaces,2019,11(28):25556-25568.
[8] Qin B,Yin Z,Tang X,et al. Supramolecular Polymer Chemistry:From Structural Control to Functional Assembly[J]. Prog Polym Sci,2019,10:101167.
[9] Zhang Y,Liu X,Zeng L,et al. Tissue Engineering: Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering[J]. Adv Funct Mater,2019,29(36):1970246.
[10] Zhang Y,Du B Y,Chen X,et al. Convergence of Dissipation and Impedance Analysis of Quartz Crystal Microbalance Studies[J]. Anal Chem,2009,81(2):642-648.
[11] Hajiraissi R,Hanke M,Yang Y,et al. Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS[J]. Langmuir,2018,34(11):3517-3524.
[12] Hu Y,Jin J,Han Y Y,et al. Study of Fibrinogen Adsorption on Poly(Ethylene Glycol)-Modified Surfaces Using a Quartz Crystal Microbalance with Dissipation and a Dual Polarization Interferometry[J]. RSC Adv,2014,4(15):7716-7724.
[13] Heidary N,Kornienko N,Kalathil S,et al. Disparity of Cytochrome Utilization in Anodic and Cathodic Extracellular Electron Transfer Pathways of Geobacter Sulfurreducens Biofilms[J]. J Am Chem Soc,2020,142(11):5194-5203.
[14] Marx K A. Quartz Crystal Microbalance:A Useful Tool for Studying Thin Polymer Films and Complex Biomolecular Systems at the Solution-Surface Interface[J]. Biomacromolecules,2003,4(5):1099-1120.
[15] Sauerbrey G. Verwendung Von Schwingquarzen Zur Wägung Dünner Schichten Und Zur Mikrowagung[J]. Zeitschrift Für Physik,1959,155(2):206-222(in German).
[16] Kanazawa K K,Gordon J G. Frequency of a Quartz Microbalance in Contact with Liquid[J]. Anal Chem,1985,57(8):1770-1771.
[17] Rodahl M,Kasemo B. On the Measurement of Thin Liquid Overlayers with the Quartz-Crystal Microbalance[J]. Sens Actuators A,1996,54(1-3):448-456.
[18] Chen T,Yang H,Gao H W,et al. Adsorption and Orientation of 3,4-Dihydroxy-L-Phenylalanine onto Tunable Monolayer Films[J]. J Phys Chem C,2017,121(21):11544-11551.
[19] Du B Y,Johannsmann D. Operation of the Quartz Crystal Microbalance in Liquids:Derivation of the Elastic Compliance of a Film from the Ratio of Bandwidth Shift and Frequency Shift[J]. Langmuir,2004,20(7):2809-2812.
[20] Ma H W,Zhu Z,Li D,et al. A Quartz Crystal Microbalance-Based Molecular Ruler for Biopolymers[J]. Chem Commun,2010,46(6):949-951.
[21] DeNolf G C,Sturdy L F,Shull K R. High-Frequency Rheological Characterization of Homogeneous Polymer Films with the Quartz Crystal Microbalance[J]. Langmuir,2014,30(32):9731-9740.
[22] Sadman K,Wiener C G,Weiss R A,et al. Quantitative Rheometry of Thin Soft Materials Using the Quartz Crystal Microbalance with Dissipation[J]. Anal Chem,2018,90(6):4079-4088.
[23] Bruckenstein S,Michalski M,Fensore A,et al. Dual Quartz Crystal Microbalance Oscillator Circuit. Minimizing Effects Due to Liquid Viscosity, Density, and Temperature[J]. Anal Chem,1994,66(11):1847-1852.
[24] HE Jian′an,FU Long,HUANG Mo,et al. The Development of Quartz Crystal Microbalance[J]. Sci Sin Chim,2011,41(11):7-26(in Chinese).
何建安,付龙,黄沫,等. 石英晶体微天平的新进展[J]. 中国科学:化学,2011,41(11):7-26.
[25] Liu G M,Zhang G Z. Reentrant Behavior of Poly(N-Isopropylacrylamide) Brushes in Water-Methanol Mixtures Investigated with a Quartz Crystal Microbalance[J]. Langmuir,2005,21(5):2086-2090.
[26] Zhang G Z. Study on Conformation Change of Thermally Sensitive Linear Grafted Poly(N-isopropylacrylamide) Chains by Quartz Crystal Microbalance[J]. Macromolecules,2004,37(17):6553-6557.
[27] Liu G M,Zhang G Z. Collapse and Swelling of Thermally Sensitive Poly(N-isopropylacrylamide) Brushes Monitored with a Quartz Crystal Microbalance[J]. J Phys Chem B,2005,109(2):743-747.
[28] He C,Liu G M,Wang C,et al. Collapse and Swelling of Poly(N-isopropylacrylamide-co-Sodium Acrylate) Copolymer Brushes Grafted on a Flat SiO₂ Surface[J]. J Polym Sci Part B Polym Phys,2006,44(4):770-778.
[29] Liu G M,Cheng H,Yan L F,et al. Study of the Kinetics of the Pancake-to-Brush Transition of Poly(N-isopropylacrylamide) Chains[J]. J Phys Chem B,2005,109(47):22603-22607.
[30] Liu G M,Yan L F,Chen X,et al. Study of the Kinetics of Mushroom-to-Brush Transition of Charged Polymer Chains[J]. Polymer,2006,47(9):3157-3163.
[31] Ji H F,Xu H,Jin L Q,et al. Surface Engineering of Low-Fouling and Hemocompatible Polyethersulfone Membranes via In-Situ Ring-Opening Reaction[J]. J Membr Sci,2019,581:373-382.
[32] Wang X W,Liu G M,Zhang G Z. Effect of Surface Wettability on Ion-Specific Protein Adsorption[J]. Langmuir,2012,28(41):14642-14653.
[33] Wu B,Liu G,Zhang G,et al. Stiff Chains Inhibit and Flexible Chains Promote Protein Adsorption to Polyelectrolyte Multilayers[J]. Soft Matter,2019,10(21):3806.
[34] Chen Y,Song Q L,Zhao J P,et al. Betulin-Constituted Multiblock Amphiphiles for Broad-Spectrum Protein Resistance[J]. ACS Appl Mater Interfaces,2018,10(7):6593-6600.
[35] JIN Jing,HU Yu,HAN Yuanyuan,et al. Modified Surface by Poly(Ethylene Glycol) with Looped Conformation and Its Superior Anticoagulant Property[J]. Sci Sin Chim,2018,48(8):972-980(in Chinese).
金晶,胡宇,韩媛媛,等. 环状构象PEG改性表面及其优越的抗凝血性能[J]. 中国科学:化学,2018,48(8):972-980.
[36] Lv J H,Jin J,Han Y Y,et al. Effect of End-Grafted PEG Conformation on the Hemocompatibility of Poly(Styrene-b-(Ethylene-co-Butylene)-b-Styrene)[J]. J Biomater Sci,2019,30(17):1670-1685.
[37] John T,Greene G W,Patil N A,et al. Adsorption of Amyloidogenic Peptides to Functionalized Surfaces Is Biased by Charge and Hydrophilicity[J]. Langmuir,2019,35(45):14522-14531.
[38] Gomez Maldonado D,Vega Erramuspe I B,Filpponen I,et al. Cellulose-Cyclodextrin Co-polymer for the Removal of Cyanotoxins on Water Sources[J]. Polymers,2019,11(12):2075.
[39] Song J,Chen C,Zhu S,et al. Processing Bulk Natural Wood into a High-Performance Structural Material[J]. Nature,2018,554(7691):224-228.
[40] Kong W,Wang C,Jia C,et al. Muscle-Inspired Highly Anisotropic, Strong, Ion-Conductive Hydrogels[J]. Adv Mater,2018,30(39):1801934.
[41] Zhang X,Zhu Y,Wang X,et al. Revealing Adsorption Behaviors of Amphoteric Polyacrylamide on Cellulose Fibers and Impact on Dry Strength of Fiber Networks[J]. Polymers,2019,11(11):1886.
[42] Jiang C,Cao T,Wu W,et al. Novel Approach to Prepare Ultrathin Lignocellulosic Film for Monitoring Enzymatic Hydrolysis Process by Quartz Crystal Microbalance[J]. ACS Sustainable Chem Eng,2017,5(5):3837-3844.
[43] Lee C H,Li Y J,Huang C C,et al. Poly(ε-caprolactone) Nanocapsule Carriers with Sustained Drug Release:Single Dose for Long-Term Glaucoma Treatment[J]. Nanoscale,2017,9(32):11754-11764.
[44] Campos J,Jiménez C,Trigo C,et al. Quartz Crystal Microbalance with Dissipation Monitoring:A Powerful Tool for Bionanoscience and Drug Discovery[J]. J Bionanosci,2015,9(4):249-260.
[45] Deligoz H,Tieke B. QCM-D Study of Layer-by-Layer Assembly of Polyelectrolyte Blend Films and Their Drug Loading-Release Behavior[J]. Colloids Surf A Physicochem Eng Asp,2014,441:725-736.
[46] Li J Y,Qu X,Payne G F,et al. Biospecific Self-assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery[J]. Adv Funct Mater,2015,25(9):1404-1417.
[47] Pashuck E T,Duchet B J R,Hansel C S,et al. Controlled Sub-nanometer Epitope Spacing in a Three-Dimensional Self-assembled Peptide Hydrogel[J]. ACS Nano,2016,10(12):11096-11104.
[48] Chirra H D,Hilt J Z. Nanoscale Characterization of the Equilibrium and Kinetic Response of Hydrogel Structures[J]. Langmuir,2010,26(13):11249-11257.
[49] Cao Z,Du B Y,Chen T,et al. Fabrication and Properties of Thermosensitive Organic/Inorganic Hybrid Hydrogel Thin Films[J]. Langmuir,2008,24(10):5543-5551.
[50] Mas Vinyals A,Gilabert Porres J,Figueras Esteve L,et al. Improving Linking Interface Between Collagen-Based Hydrogels and Bone-Like Substrates[J]. Colloid Surf B,2019,181:86-871.
[51] Zhang M X,Wiener C G,Sepulveda-Medina P I,et al. Influence of Sodium Salts on the Swelling and Rheology of Hydrophobically Cross-Linked Hydrogels Determined by QCM-D[J]. Langmuir,2019,35(50):16612-16623.