中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (11): 1272-1275.DOI: 10.3724/SP.J.1095.2010.00098

• 研究论文 • 上一篇    下一篇

乙酰丙酮氧钒催化氧化α-蒎烯一步转化成龙脑烯醛

肖毅1,2,黄红梅1,毛丽秋1,2,周 亮2,徐 琼1,2,王季惠2,尹笃林1,2*   

  1. (1.化学生物学及中药分析教育部重点实验室，2.湖南师范大学精细催化合成研究所 长沙 410081)
  • 收稿日期:2010-02-05 修回日期:2010-04-16 出版日期:2010-11-10 发布日期:2010-11-10
  • 通讯作者: 尹笃林，男，教授，博士生导师; E-mail:dulinyin@yahoo.com.cn; 研究方向：有机催化合成
  • 基金资助:
    国家自然科学基金(20572021，20805014，20976043)湖南省自然科学基金(09JJ3018)资助项目

One-step Conversion of α-Pinene to Campholenic Aldehyde via VO(acac)2-catalyzed Oxidation

XIAO Yi1,2, HUANG Hong-Mei1, MAO Li-Qiu1,2, ZHOU Liang2, XU Qiong1,2, WANG Ji-Hui2, YIN Du-Lin1,2*   

  1. (1.Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education;
    2.Institute of Fine Catalysis and Synthesis,Hunan Normal University,Changsha 410081)
  • Received:2010-02-05 Revised:2010-04-16 Published:2010-11-10 Online:2010-11-10

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摘要：

以乙酰丙酮氧钒为催化剂，过氧化氢为氧化剂， 研究了由α-蒎烯直接合成龙脑烯醛的反应。 考察了溶剂、温度、催化剂用量、反应时间等因素对催化性能的影响。 结果表明， 乙酰丙酮氧钒与H2O2反应得到的高价态V5+是优良的氧化还原-Lewis酸双功能催化剂，易使α-蒎烯经氧化、2，3-环氧蒎烷异构得到龙脑烯醛。 在n(H2O2)∶n(α-蒎烯)∶n(乙酰丙酮氧钒)=2.5∶1∶0.01、反应温度为20 ℃、丙酮为溶剂、反应2 h条件下，α-蒎烯转化率为50.2%，龙脑烯醛的选择性达58.7%，反应6 h后α-蒎烯转化率可达73.0%，主要产物龙脑烯醛和马鞭草烯酮的选择性分别为47.2%和13.2%。

关键词: 乙酰丙酮氧钒, α-蒎烯, 龙脑烯醛, 过氧化氢, 催化氧化

Abstract:

Conversion of α-pinene to campholenic aldehyde was directly carried out with aqueous hydrogen peroxide as oxidant catalyzed by VO(acac)2. The effects of reaction conditions such as solvents, temperature, dosage of catalyst and time on this reaction were investigated. The results showed that high valent V5+ obtained from VO(acac)2 and H2O2 is a good redox-Lewis acid bi-functional catalyst for the transformation of α-pinene to campholenic aldehyde via oxidation and isomerization of 2,3-epoxy pinane intermediate. Under optimal reaction conditions of n(H2O2)∶n(α-pinene)∶n(VO(acac)2)=2.5∶1∶0.01, reaction temperature 20 ℃, using acetone as solvent, 58.7% selectivity of campholenic aldehyde was achieved at 50.2% conversion of α-pinene after 2 h reaction. Reacting for 6 h under the conditions described above, conversion of α-pinene can reach up to 73.0% and selectivity of major products campholenic aldehyde and verbenone were 47.2% and 13.2%, respectively.

Key words: VO( acac)2, α-pinene, campholenic aldehyde, hydrogen peroxide, catalytic oxidation

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