Structural Regulation and Antibacterial Properties of Poly （Sodium-p-Styrene Sulfonate） and Quaternary Phosphonium Surfactanls Complexes

doi:10.19894/j.issn.1000-0518.230341

Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (4): 521-528.DOI: 10.19894/j.issn.1000-0518.230341

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Structural Regulation and Antibacterial Properties of Poly （Sodium-p-Styrene Sulfonate） and Quaternary Phosphonium Surfactanls Complexes

Bo-Rui LIU¹^,², Chang-Jun MU³, Yu BAN¹(), Lei WANG¹, Qiu-Yan YAN¹, Heng-Chong SHI¹^,²(), Jing-Hua YIN¹, Shi-Fang LUAN¹^,²

^1.State Key Laboratory of Polymer Physics and Chemistry，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun 130022，China
^2.School of Applied Chemistry and Engineering，University of Science and Technology of China，Hefei 230026，China
^3.Shandong Weigao Blood Purification Products Co. ，Ltd. ，Weihai 264200，China

Received:2023-10-31 Accepted:2024-02-01 Published:2024-04-01 Online:2024-04-28
Contact: Yu BAN,Heng-Chong SHI
About author:shihc@ciac.ac.cn
yuban@ciac.ac.cn；
Supported by:
the National Natural Science Foundation of China(52293384);Scientific and Technological Development Program of Jilin Province(20220508090RC);Chinese Academy of Sciences-Wego Group Hightech Research & Development Program

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Abstract

Abstract:

Development of non-antibiotic antibacterial strategies in reducing medical apparatus and instruments related to bacterial infection and reducing the over reliance of antibiotics is of great significance. Surface functionalization of medical apparatus， which gives it antibacterial properties is adopted by way of commonly used in non-antibiotics antibacterial strategies. Polyelectrolyte complexes have the advantages in the simple construction of antibacterial coating， considering it could be soluble in ethanol and insoluble in water， not limited by the instrument structure. It is expected to be applied to all kinds of surface functionalization of medical apparatus and instruments. We report comprehensive analysis on the interaction of polyelectrolyte-surfactant complexes （PSCX） that consist of sodium polystyrenesulfonate （PSS） and different alkyl tributylphosphonium （3BuCX， with chain lengths ranging from 8 to 16） based cationic surfactants， using several techniques with turbidimetry， isothermal titration calorimetry （ITC） and so on. System assembly behavior of compound in aqueous solution was studied， as well as the intrinsic connection between the antibacterial properties of the preparation of compound coating with surfactant component and the hydrophobic carbon chain lengths. The results indicate that increasing the alkyl chain length of surfactant promotes the formation process of PSCX. By constructing complex coatings， we compared the antibacterial properties of PSCX with different alkyl chain lengths. For S.?aureus， the antibacterial properties of PSCX corresponding three coatings were also improved with the antibacterial rates of 42.9%， 99.97% and 99.99%， respectively， which increased with the alkyl chain of the surfactant. For E.coli， with the increase of surfactant alkyl chain length， the better the antibacterial activity of the surfactant alone was achieved， while the antibacterial activity of the PSCX coating were decreased， with the bactericidal rates were 99.3%， 92.3% and 64.8%， respectively. These results indicate that the PSCX coating can be used to reduce the infection of medical devices by optimizing its structure.

Key words: Poly （sodium-p-styrene sulfonate） complex, Sodium polystyrenesulfonate, Quaternary phosphonium surfactant, Coating, Antimicrobial

CLC Number:

O631

Bo-Rui LIU, Chang-Jun MU, Yu BAN, Lei WANG, Qiu-Yan YAN, Heng-Chong SHI, Jing-Hua YIN, Shi-Fang LUAN. Structural Regulation and Antibacterial Properties of Poly （Sodium-p-Styrene Sulfonate） and Quaternary Phosphonium Surfactanls Complexes[J]. Chinese Journal of Applied Chemistry, 2024, 41(4): 521-528.

Figures/Tables 7

Fig.1 Molecular structure of PSS and 3BuCX （X=6， 8， 12， 16）

Fig.2 The transmittance of PSCX （X=6， 8， 12， 16） systems with different DN values

Fig.3 Calorimetric titration of 3BuC8 （A， 12.65 mmol/L）和3BuC16 （B， 9.85 mmol/L） into PSS solution （1.46 mmol/L sulfonic acid groups） at 298 K；（top panel） CFB curves versus time；（bottom panel） differential enthalpy curves versus DN value

Fig.4 Binding isotherms obtained from titrating 3BuCX in PSS， plotted together with the dilution curves

Table 1 Thermodynamic parameters for binding and micellization of 3BuCX in PSS solution at reference temperature T=298 K

$Δ G e l e$ /

（kJ·mol^-1）

$Δ H e l e /$

（kJ·mol^-1）

$Δ S e l e$ /

（J·mol^-1·K^-1）

$Δ G h y d r o /$

（kJ·mol^-1）

$Δ H h y d r o /$

（kJ·mol^-1）

$Δ S h y d r o /$

（J·mol^-1 ·K^-1）

Table 1 Thermodynamic parameters for binding and micellization of 3BuCX in PSS solution at reference temperature T=298 K

$Δ G e l e$ /

（kJ·mol^-1）

$Δ H e l e /$

（kJ·mol^-1）

$Δ S e l e$ /

（J·mol^-1·K^-1）

$Δ G h y d r o /$

（kJ·mol^-1）

$Δ H h y d r o /$

（kJ·mol^-1）

$Δ S h y d r o /$

（J·mol^-1 ·K^-1）

PSC8

-38.05

34.31

242.70

-26.12

5.97

107.6

PSC16

-29.20

11.01

134.87

-51.14

14.81

221.2

Table 2 The MIC of quaternary phosphonium surfactants with different alkyl chain length against S. aureus and E. coli

	3BuC8	3BuC12	3BuC16
S. aureus	20 μg/mL （50.0 μmol/L）	1.5 μg/mL （3.3 μmol/L）	1.5 μg/mL （2.9 μmol/L）
E. coli	3 mg/mL （7.6 mmol/L）	20 μg/mL （44.3 μmol/L）	5 μg/mL （9.8 μmol/L）

Fig.5 Number of colony forming units （CFU） of S.?aureus （A） and E.coli （B） before （TPU） and after coating PSCX on the TPU plane. Antibacterial activity of TPU-PSCX toward S.aureus and E.?coli， where error bars represent standard deviations of data for three separate measurements. *： P＜0.05， **： P＜0.01， ***： P＜0.001

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Structural Regulation and Antibacterial Properties of Poly （Sodium-p-Styrene Sulfonate） and Quaternary Phosphonium Surfactanls Complexes

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