Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (4): 521-528.DOI: 10.19894/j.issn.1000-0518.230341

• Full Papers • Previous Articles     Next Articles

Structural Regulation and Antibacterial Properties of Poly (Sodium-p-Styrene Sulfonate) and Quaternary Phosphonium Surfactanls Complexes

Bo-Rui LIU1,2, Chang-Jun MU3, Yu BAN1(), Lei WANG1, Qiu-Yan YAN1, Heng-Chong SHI1,2(), Jing-Hua YIN1, Shi-Fang LUAN1,2   

  1. 1.State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
    2.School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China
    3.Shandong Weigao Blood Purification Products Co. ,Ltd. ,Weihai 264200,China
  • Received:2023-10-31 Accepted:2024-02-01 Published:2024-04-01 Online:2024-04-28
  • Contact: Yu BAN,Heng-Chong SHI
  • About author:shihc@ciac.ac.cn
    yuban@ciac.ac.cn
  • Supported by:
    the National Natural Science Foundation of China(52293384);Scientific and Technological Development Program of Jilin Province(20220508090RC);Chinese Academy of Sciences-Wego Group Hightech Research & Development Program

Abstract:

Development of non-antibiotic antibacterial strategies in reducing medical apparatus and instruments related to bacterial infection and reducing the over reliance of antibiotics is of great significance. Surface functionalization of medical apparatus, which gives it antibacterial properties is adopted by way of commonly used in non-antibiotics antibacterial strategies. Polyelectrolyte complexes have the advantages in the simple construction of antibacterial coating, considering it could be soluble in ethanol and insoluble in water, not limited by the instrument structure. It is expected to be applied to all kinds of surface functionalization of medical apparatus and instruments. We report comprehensive analysis on the interaction of polyelectrolyte-surfactant complexes (PSCX) that consist of sodium polystyrenesulfonate (PSS) and different alkyl tributylphosphonium (3BuCX, with chain lengths ranging from 8 to 16) based cationic surfactants, using several techniques with turbidimetry, isothermal titration calorimetry (ITC) and so on. System assembly behavior of compound in aqueous solution was studied, as well as the intrinsic connection between the antibacterial properties of the preparation of compound coating with surfactant component and the hydrophobic carbon chain lengths. The results indicate that increasing the alkyl chain length of surfactant promotes the formation process of PSCX. By constructing complex coatings, we compared the antibacterial properties of PSCX with different alkyl chain lengths. For S.?aureus, the antibacterial properties of PSCX corresponding three coatings were also improved with the antibacterial rates of 42.9%, 99.97% and 99.99%, respectively, which increased with the alkyl chain of the surfactant. For E.coli, with the increase of surfactant alkyl chain length, the better the antibacterial activity of the surfactant alone was achieved, while the antibacterial activity of the PSCX coating were decreased, with the bactericidal rates were 99.3%, 92.3% and 64.8%, respectively. These results indicate that the PSCX coating can be used to reduce the infection of medical devices by optimizing its structure.

Key words: Poly (sodium-p-styrene sulfonate) complex, Sodium polystyrenesulfonate, Quaternary phosphonium surfactant, Coating, Antimicrobial

CLC Number: