Quantitative Analysis of Residual Nonylcyclohexanol in Nonylcyclohexanol Polyoxyethylene Ethers by  Normal Phase High Performance Liquid Chromatography

doi:10.11944/j.issn.1000-0518.2020.07.200017

Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (7): 816-822.DOI: 10.11944/j.issn.1000-0518.2020.07.200017

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Quantitative Analysis of Residual Nonylcyclohexanol in Nonylcyclohexanol Polyoxyethylene Ethers by Normal Phase High Performance Liquid Chromatography

HU Xueyi^a, HU Yitao^a, FANG Yun^a,*, XIA Yongmei^a, QIAN Fei^b

^aThe Key Laboratory of Synthetic and Biological ColloidsMinistry of Education,School of Chemical and Materials Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China;
^bJiangsu Lingfei Technology Co.,Ltd.,Wuxi,Jiangsu 214264,China

Received:2020-01-15 Published:2020-07-01 Online:2020-07-07
Contact: FANG Yun, professor; Tel:0510-85917920; E-mail:yunfang@126.com; Research interests:colloid and interface chemistry
Supported by:
Supported by the National Key Research and Development Plan of China(No.2017YFB0308904)

Abstract

Abstract: Nonylcyclohexanol polyoxyethylene ethers (NCEO_n) are novel potential upgraded products for replacing the non-eco-friendly nonylphenol polyoxyethylene ethers (NPEO_n). The product qualities of NCEO_n were determined revolving the residual nonylcyclohexanol (NC) by normal phase high performance liquid chromatography (NP HPLC), the polyethylene glycol (PEG) content by Weilbull procedure and the polydispersity index (PDI) by electrospray ionization mass spectrometry (ESI MS) technique. An NP HPLC program was finally proposed for rapidly determining the residual NC in NCEO_n by combining an Inertsil NH₂ column, a refractive index detector with the eluent of ethyl acetate on the basis of five preliminary experiments of NP HPLC and reversed phase HPLC. This setup achieves a recovery of 91.77%~107.6%, a relative standard deviation (RSD) of 1.59%~4.46% and a limit of detection (LOD) 9.8 μg/mL. NCEO₇ and NCEO₉ contain 0.158% and 0.139% of NC, and 7.1% and 7.3% of PEG, respectively, which indicates that the NCEO_n products have good qualities with a low NC residue, a low PEG content and a narrow distribution characteristic. Therefore, NCEO_n is a potential substitute of NPEO_n used in daily chemicals such as cosmetics, personal care products and toiletries.

Key words: nonylcyclohexanol polyoxyethylene ether, nonylcyclohexanol, high performance liquid chromatography, analysis, nonylphenol polyoxyethylene ether

HU Xueyi, HU Yitao, FANG Yun, XIA Yongmei, QIAN Fei. Quantitative Analysis of Residual Nonylcyclohexanol in Nonylcyclohexanol Polyoxyethylene Ethers by Normal Phase High Performance Liquid Chromatography[J]. Chinese Journal of Applied Chemistry, 2020, 37(7): 816-822.

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Quantitative Analysis of Residual Nonylcyclohexanol in Nonylcyclohexanol Polyoxyethylene Ethers by Normal Phase High Performance Liquid Chromatography

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