Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (7): 816-822.DOI: 10.11944/j.issn.1000-0518.2020.07.200017

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Quantitative Analysis of Residual Nonylcyclohexanol in Nonylcyclohexanol Polyoxyethylene Ethers by Normal Phase High Performance Liquid Chromatography

HU Xueyia, HU Yitaoa, FANG Yuna,*, XIA Yongmeia, QIAN Feib   

  1. aThe Key Laboratory of Synthetic and Biological ColloidsMinistry of Education,School of Chemical and Materials Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China;
    bJiangsu Lingfei Technology Co.,Ltd.,Wuxi,Jiangsu 214264,China
  • Received:2020-01-15 Published:2020-07-01 Online:2020-07-07
  • Contact: FANG Yun, professor; Tel:0510-85917920;; Research interests:colloid and interface chemistry
  • Supported by:
    Supported by the National Key Research and Development Plan of China(No.2017YFB0308904)

Abstract: Nonylcyclohexanol polyoxyethylene ethers (NCEOn) are novel potential upgraded products for replacing the non-eco-friendly nonylphenol polyoxyethylene ethers (NPEOn). The product qualities of NCEOn were determined revolving the residual nonylcyclohexanol (NC) by normal phase high performance liquid chromatography (NP HPLC), the polyethylene glycol (PEG) content by Weilbull procedure and the polydispersity index (PDI) by electrospray ionization mass spectrometry (ESI MS) technique. An NP HPLC program was finally proposed for rapidly determining the residual NC in NCEOn by combining an Inertsil NH2 column, a refractive index detector with the eluent of ethyl acetate on the basis of five preliminary experiments of NP HPLC and reversed phase HPLC. This setup achieves a recovery of 91.77%~107.6%, a relative standard deviation (RSD) of 1.59%~4.46% and a limit of detection (LOD) 9.8 μg/mL. NCEO7 and NCEO9 contain 0.158% and 0.139% of NC, and 7.1% and 7.3% of PEG, respectively, which indicates that the NCEOn products have good qualities with a low NC residue, a low PEG content and a narrow distribution characteristic. Therefore, NCEOn is a potential substitute of NPEOn used in daily chemicals such as cosmetics, personal care products and toiletries.

Key words: nonylcyclohexanol polyoxyethylene ether, nonylcyclohexanol, high performance liquid chromatography, analysis, nonylphenol polyoxyethylene ether