Application and Progress of Perylenediimides Derivatives in Treating Tumor

doi:10.11944/j.issn.1000-0518.2017.06.160356

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (6): 611-622.DOI: 10.11944/j.issn.1000-0518.2017.06.160356

• Review • Next Articles

Application and Progress of Perylenediimides Derivatives in Treating Tumor

Xiang LI^a^b,Yingying JIN^a^b,Yibo LIU^a,Zhen ZHAO^a,Xiao LI^a,Fang CHENG^a,Zhonghua LIU^a^*(),Yongwei HUANG^a^*()

^aLaboratory for Medical Nanomaterials,School of Base Medical Science
^bHuaihe Clinical Institute,Henan University,Kaifeng,Henan 475000,China

Received:2016-09-06 Accepted:2017-01-17 Published:2017-05-31 Online:2017-05-31
Contact: Zhonghua LIU,Yongwei HUANG
Supported by:
Supported by the National Natural Science Foundation of China(No.21572045), Project of Science and Technology Department of Henan Province(No.162102310074), China Postdoctoral Science Foundation(No.2013M530335, No.2015T80767), Program for Science & Technology Innovation Talents in the Universities of Henan Province(No.16HASTIT008), Scientific Research Fund project of Henan University(No.xxjc20140019)

Abstract

Abstract:

At present, malignant tumor has been becoming the main threat to human's death. Chemotherapy is one of the main methods of tumor therapy. However, there are many defects, such as side effects, drug resistance and difficulty of monitoring. Most of research works focus on improving the drugs' therapeutic effect and cutting down it's side effects, drugs' carriers are used to increase its concentration in the local lesions, which promote the efficiency of inhibiting tumor cells and reduce side effects with antitumor drugs. Perylenediimides derivatives(PDI) is a highly stable fluorescing materials, which is easily modified to enhance its biocompatibility and exercise a variety of functions. It can be used as drug carriers, fluorescence imaging, and anticancer drugs for cancers' diagnosis and treatment. This review focuses on the recent progress of PDI's biomedical applications and elaborates from drug carrier, antitumor drugs and fluorescent tracer aspects. This review summarized the basic experimental theory and gave the way for the application of PDI in clinical work.

Key words: tumor, perylenediimides, nanocarriers, fluorescence image

Xiang LI,Yingying JIN,Yibo LIU,Zhen ZHAO,Xiao LI,Fang CHENG,Zhonghua LIU,Yongwei HUANG. Application and Progress of Perylenediimides Derivatives in Treating Tumor[J]. Chinese Journal of Applied Chemistry, 2017, 34(6): 611-622.

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Application and Progress of Perylenediimides Derivatives in Treating Tumor

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