Synthesis and Antitumor Activity of Hexahydro-1H-pyrrolo [3,4-d] Pyrimidine Derivatives

doi:10.11944/j.issn.1000-0518.2017.05.160191

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (5): 541-549.DOI: 10.11944/j.issn.1000-0518.2017.05.160191

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Synthesis and Antitumor Activity of Hexahydro-1H-pyrrolo [3,4-d] Pyrimidine Derivatives

LI Na^a^*(),LI Hui^b

^aCollege of Pharmacy
^bSanquan College,Xinxiang Medical University,Xinxiang,He'nan 453003,China

Received:2016-05-09 Accepted:2016-09-07 Published:2017-05-02 Online:2017-05-02
Contact: LI Na
Supported by:
Supported by the Industry, University, Research Project of He'nan(No.132107000035)

Abstract

Abstract:

Using maleic anhydride as the starting material, hexahydro-1H-pyrrolo[3,4-d] pyrimidine derivatives were synthesized. The structures of all compounds were characterized by ¹H NMR, ¹³C NMR, ESI-MS and elemental analysis. Their antitumor activities against Bel-740 human liver cancer cells were determined by the 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT) assay. The results indicate that these compounds have a certain inhibitory activity in Bel-740 human liver cancer cells, and the inhibitory activity of compounds 9d and 9g reach the average level.

Key words: maleic anhydride, curtius rearrangement, hexahydro-1H-pyrrolo [3,4-d] pyrimidine derivatives, antitumor activity

LI Na,LI Hui. Synthesis and Antitumor Activity of Hexahydro-1H-pyrrolo [3,4-d] Pyrimidine Derivatives[J]. Chinese Journal of Applied Chemistry, 2017, 34(5): 541-549.

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Synthesis and Antitumor Activity of Hexahydro-1H-pyrrolo [3,4-d] Pyrimidine Derivatives

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