Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (9): 977-984.DOI: 10.11944/j.issn.1000-0518.2020.09.200164

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Enhancing T Cell Antitumor Activity by Regulating Tumor Metabolism

ZHANG Sijiaa,b, XU Cainaa, CHEN Jiea,b, TIAN Huayua,b*, CHEN Xuesia,b   

  1. aKey Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;
    bUniversity of Science and Technology of China,Hefei 230026,China
  • Received:2020-06-01 Published:2020-09-01 Online:2020-09-09
  • Contact: TIAN Huayu, professor; Tel/Fax:0431-85262539; E-mail:thy@ciac.ac.cn; Research interests:biomedical polymer
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.51925305, No.51873208, No.51520105004, No.51833010) and the Jilin Province Science and Technology Development Program(No.20180414027GH)

Abstract: Tumor immunotherapy is a new technique for cancer treatment. However, the low clinical response rate of tumor immunotherapy at this stage seriously restricts its further application. The fundamental reason is that the immunosuppressive microenvironment of tumor tissue limits the antitumor activity of T cells, and the metabolic changes of tumor tissue play a key role in the formation of tumor immunosuppressive microenvironment. In this paper, we focus on enhancing the antitumor activity of T cells by regulating the aerobic glycolysis, amino acid metabolism and fatty acid metabolism of tumors. Finally, the current problems in the research of tumor metabolism regulation are proposed, and the development prospects of nanocarriers in the field of tumor metabolism are prospected.

Key words: tumor metabolism, T cell antitumor activity, aerobic glycolysis, amino acid metabolism, fatty acid metabolism