Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (7): 743-747.DOI: 10.11944/j.issn.1000-0518.2015.07.140383

• Full Papers • Previous Articles     Next Articles

Dipeptide-Catalyzed Direct Asymmetric Chlorination of Aldehydes in Zn[CO(NH2)2]3Cl2 Ionic Liquid

ZHANG Baohuaa, SHI Lanxianga, *, LIU Shengbaob   

  1. aCollege of Chemical Engineering,Shijiazhuang University,Shijiazhaung 050035,China
    bBaoding Traditional Chinese Medicine Pharmaco.,Itd,Baoding,Hebei 071200,China
  • Received:2014-11-06 Accepted:2015-03-27 Published:2015-06-30 Online:2015-06-30
  • Contact: Lanxiang SHI
  • Supported by:
    Supported by Hebei Province Science and Technology Support Projects (No13964002D) and Shijiazhuang College Platform Project Funds (NoXJPT007)

Abstract:

A method for direct asymmetric chlorination of aldehydes and 2,3,4,5,6,6-hexachloro-2,4-cyclohexadien-1-one catalyzed by Pro-Trp in the presence of N-methylmorpholine (NMM) and ionic liquid Zn[CO(NH2)2]3Cl2 has been developed. This method produces the corresponding optically active chlorinated products with high yields (up to 95%) and good enantioselectivities (up to 92%ee). The approach has advantages in simple isolation and reusablility of catalyst and ionic liquids.

 

Key words: hexachloro-cyclohexadien-one, ionic liquid, dipeptide, chlorination, aldehyde

CLC Number: